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Em dezembro de 2019, considerando a data da sua promulgação, a Emenda Constitucional n. 45, de 30 de dezembro de 2004, completou 15 (quinze) anos. O que, formal e substancialmente, as alterações provenientes da chamada “Reforma do Poder Judiciário” representaram para o segmento da Justiça do Trabalho?A observação crítica dessa trajetória hermenêutica, que entrelaça texto e contexto interpretativo, é uma tarefa árdua, mas, necessária para comunicar no tempo presente os desafios futuros de uma práxis constitucional compromissária dos direitos sociais fundamentais e do seu sistema de garantias.A alteração constitucional em questão ampliou, de forma significativa, a compe...
"The exponential influx of scientific research on melatonin is associated with a greater orientation towards the study of the systemic effects of melatonin and their derivatives, as well as their clinical implications. Proof of this fact is summarized in the present compilation, where melatonin is presented as a remarkable agent to counteract most of the physiopathological events that trigger several disorders. The book also collects evidence about melatonin's interactions with two high-affinity G protein-coupled receptors to provide new pharmacological targets for the treatment of cancer, neurological or endocrine conditions. The present review also includes detailed coverage of molecules w...
Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. The synthesis and release of melatonin are stimulated by darkness and suppressed by light, suggesting the involvement of melatonin in circadian rhythm and regulation of diverse body functions. Levels of melatonin start to increase prior to bedtime. Synthetic melatonin supplements have been used for a variety of medical conditions, most notably for disorders related to sleep. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This important book presents a full spectrum of research on melatonin and is destined to become an essential reference for anyone interested in melatonin.
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Nesta obra, o autor aborda questões sobre a produção do conhecimento científico, do princípio epistemológico que fundamenta o ato de conhecer e as implicações dessas questões no trabalho docente. Norteado por referências nas áreas de história e filosofia da ciência, formação de professores, metodologia, didática, temática ambiental e educação ambiental, abordou o seguinte problema de pesquisa: como se processa, em termos lógicos, a organização do conhecimento (método) de uma professora iniciante, para o trabalho educativo com a temática ambiental, em uma escola formadora de técnicos em meio ambiente? Conduziu a pesquisa, a hipótese de que subordinado à organização metodológica do conteúdo de ensino, trabalhado por uma professora iniciante, encontra-se um princípio lógico que norteia essa organização, podendo o mesmo ser de caráter formal ou dialético. Essa hipótese conduziu a pesquisa a uma síntese de que a lógica formal clássica, de base aristotélica, é o sustentáculo da organização metodológica do conteúdo de ensino trabalhado pela professora iniciante, pesquisada neste estudo de caso.
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"The year 2020 is a milestone for several important health and development goals, including for efforts to reduce the burden of malaria overall and eliminate the disease where possible. It is 20 years since the Abuja Declaration and the launch of the Millennium Development Goals (MDGs); and 5 years since the global agreement on the Sustainable Development Goals (SDGs) framework and the launch of the World Health Organization (WHO) Global technical strategy for malaria 2016–2030 (GTS) and the RBM Partnership to End Malaria Action and investment to defeat malaria 2016–2030 (AIM). The WHO World malaria report 2020 presents both the estimates of disease burden for 2019 and a review of the updated official estimates of global progress in the fight against malaria in the first 2 decades of the 21st century (2000–2019)" -- introduction.
Procedural law is no longer a purely domestic topic. The recent tendencies characterizing the field, such as Europeanization and harmonization, mark the evolution towards a new, cross-border dimension of this area of law. In addition, the growing importance of transnational legal relations in all spheres of civil and commercial dealings make it unavoidable to face the new challenges of procedural law across national borders. The traditional methods of national dogmatics, which have for a long time guided the reflections of scholars operating in the field of civil procedure, are not necessarily able to capture the increased complexity of the present. In light of this, it is particularly impor...