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Human Evolutionary Genetics
Human Evolutionary Genetics is a groundbreaking text which for the first time brings together molecular genetics and genomics to the study of the origins and movements of human populations. Starting with an overview of molecular genomics for the non-specialist (which can be a useful review for those with a more genetic background), the book shows h
Bushmen
A comprehensive and fascinating account of all the major groups of southern African hunter-gatherers.
Future Humans
"Evolutionary biologist Scott Solomon draws on the explosion of discoveries in recent years to examine the future evolution of our species. Combining knowledge of our past with current trends, Solomon offers convincing evidence that evolutionary forces still affect us today. But how will modernization--including longer lifespans, changing diets, global travel, and widespread use of medicine and contraceptives--affect our evolutionary future?" --publisher description.
Why Only Us
Berwick and Chomsky draw on recent developments in linguistic theory to offer an evolutionary account of language and humans' remarkable, species-specific ability to acquire it. “A loosely connected collection of four essays that will fascinate anyone interested in the extraordinary phenomenon of language.” —New York Review of Books We are born crying, but those cries signal the first stirring of language. Within a year or so, infants master the sound system of their language; a few years after that, they are engaging in conversations. This remarkable, species-specific ability to acquire any human language—“the language faculty”—raises important biological questions about langu...
From the Dust of the Earth
The claim that evolution undermines Christianity is standard fare in our culture. Indeed, many today have the impression that the two are mutually exclusive and that a choice must be made between faith and reason—rejecting Christianity on the one hand or evolutionary theory on the other. Is there a way to square advances in this field of study with the Bible and Church teaching? In this book—his fourth dedicated to applying Joseph Ratzinger/Benedict XVI’s wisdom to pressing theological difficulties—Matthew Ramage answers this question decidedly in the affirmative. Distinguishing between evolutionary theory properly speaking and the materialist attitude that is often conflated with it...
Genomic Advances and Challenges in Old and New World Camelids
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
AACR 2019 Proceedings: Abstracts 2749-5314
American Association for Cancer Research 2019 Proceedings: Abstracts 2749-5314 - Part B
Focus on Malignant Pleural Mesothelioma Immunology and Immunotherapy
Malignant pleural mesothelioma (MPM) is a rare thoracic cancer that derives from the mesothelial cells of the pleura and is causally associated with exposure to asbestos. Because of its aggressiveness and resistance to therapies, MPM prognosis is extremely poor and the 5-year survival rate is approximately 10%. Despite its poor effectiveness, chemotherapy with cisplatin and pemetrexed has long remained the standard-of-care for upfront treatment with no second line therapy available. Recently, the approval of ipilimumab (anti-CTLA-4) plus nivolumab (anti-PD-1) for the first-line treatment of unresectable MPM has marked a significant milestone, in particular for the non-epithelioid MPM subtype...
Antimicrobial Peptides and Complement – Maximising the Inflammatory Response
Antimicrobial peptides and complement are distinct components of the innate immune defence. While antimicrobial peptides, after cleavage of a preproprotein, have the ability to insert directly in non host membranes, complement requires a sequential enzymatic activation in the fluid phase in order to produce a transmembrane membrane attack complex. Its insertion is controlled by membrane bound regulators. Deficiencies are described for both effectors and relate to increased susceptibility of infection. In addition, however, antimicrobial peptides and complement each influence the activity of inflammatory cells as recent data in the respective research areas shows. This series of articles draws together for the entities of antimicrobial peptides and complement a balance of contributions in the areas of evolution, roles, functions and preclinical applications. By comparing and contrasting antimicrobial peptides and complement, greater cross-disciplinary appreciation will be derived for their individual and overlapping spectra of activity, circumstances of activation and their general ability to more completely inform the inflammatory and cellular response.
