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Human Evolutionary Genetics
Human Evolutionary Genetics is a groundbreaking text which for the first time brings together molecular genetics and genomics to the study of the origins and movements of human populations. Starting with an overview of molecular genomics for the non-specialist (which can be a useful review for those with a more genetic background), the book shows h
Dna, Race, and Reproduction
A free ebook version of this title is available through Luminos, University of California Press's Open Access publishing program. Visit www.luminosoa.org to learn more. DNA, Race, and Reproduction helps readers inside and outside of academia evaluate and engage with the current genomic landscape. It brings together expertise in law, medicine, religion, history, anthropology, philosophy, and genetics to examine how scientists, medical professionals, and laypeople use genomic concepts to construct racial identity and make or advise reproductive decisions, often at the same moment. It critically and accessibly interrogates how DNA figures in the reproduction of racialized bodies and the racialization of reproduction and examines the privileged position from which genomic knowledge claims to speak about human bodies, societies, and activities. The volume begins from the premise that reproduction, regardless of the means, forces a confrontation between biomedical, scientific, and popular understandings of genetics, and that those understandings are often racialized. It therefore centers reproduction as both a site of analysis and an analytic lens.
Future Humans
"Evolutionary biologist Scott Solomon draws on the explosion of discoveries in recent years to examine the future evolution of our species. Combining knowledge of our past with current trends, Solomon offers convincing evidence that evolutionary forces still affect us today. But how will modernization--including longer lifespans, changing diets, global travel, and widespread use of medicine and contraceptives--affect our evolutionary future?" --publisher description.
Predictive Medicine for Rookies
This book is meant to empower the general consumer with knowledge about DNA testing for predisposition to diseases or for deep maternal and paternal ancestry when written records are absent. At home-genetic testing needs watchdogs, Web sites, and guidebooks to interpret test results in plain language for those with no science background. Online, you'll find genetic tests for ancestry or for familial (genetic, inherited) disease risks. What helpful suggestions do general consumers with no science background need to consider? What's new in medical marketing is genetic testing online for predisposition to diseases--such as breast cancer or blood conditions. Kits usually are sent directly to the consumer who returns a mouthwash or swab DNA sample by mail. What type of training do healthcare teams need in order to interpret the results of these tests to consumers? Once you receive the results of online genetic testing kits, how do you interpret it? If your personal physician isn't yet trained to interpret the results of online genetic tests, how can you find a healthcare professional that is trained?
AACR 2022 Proceedings: Part A Online-Only and April 10
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Antimicrobial Peptides and Complement – Maximising the Inflammatory Response
Antimicrobial peptides and complement are distinct components of the innate immune defence. While antimicrobial peptides, after cleavage of a preproprotein, have the ability to insert directly in non host membranes, complement requires a sequential enzymatic activation in the fluid phase in order to produce a transmembrane membrane attack complex. Its insertion is controlled by membrane bound regulators. Deficiencies are described for both effectors and relate to increased susceptibility of infection. In addition, however, antimicrobial peptides and complement each influence the activity of inflammatory cells as recent data in the respective research areas shows. This series of articles draws together for the entities of antimicrobial peptides and complement a balance of contributions in the areas of evolution, roles, functions and preclinical applications. By comparing and contrasting antimicrobial peptides and complement, greater cross-disciplinary appreciation will be derived for their individual and overlapping spectra of activity, circumstances of activation and their general ability to more completely inform the inflammatory and cellular response.
From the Dust of the Earth
The claim that evolution undermines Christianity is standard fare in our culture. Indeed, many today have the impression that the two are mutually exclusive and that a choice must be made between faith and reason—rejecting Christianity on the one hand or evolutionary theory on the other. Is there a way to square advances in this field of study with the Bible and Church teaching? In this book—his fourth dedicated to applying Joseph Ratzinger/Benedict XVI’s wisdom to pressing theological difficulties—Matthew Ramage answers this question decidedly in the affirmative. Distinguishing between evolutionary theory properly speaking and the materialist attitude that is often conflated with it...
The Genetic Basis of Common Diseases
Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult diseases, and we now have a better understanding of the molecular processes involved in genetic susceptibility and diseases mechanisms. The second edition fully incorporates these advances. The entire book has been updated and twelve new chapters have been added. Most of these chapters deal with diseases such as gallstones, osteoporosis, osteoarthritis, skin cancer, other common skin diseases, prostate cancer and migraine headaches that are seen by all physicians. Others address the genetic and molecular basis of spondylarthropathies, lupus, hemochromatosis, IgA deficiency, mental retardation, hearing loss, and the role of mitochondrial variation in adult diseases. Chapters on the evolution of human genetic disease and on animal models add important background on the omplexities of these diseases. Unique clinical applications of genetics to common diseases are covered in the additional new chapters on genetic counseling, pharmacogenetics, and the genetic consequences of modern therapeutics.
Focus on Malignant Pleural Mesothelioma Immunology and Immunotherapy
Malignant pleural mesothelioma (MPM) is a rare thoracic cancer that derives from the mesothelial cells of the pleura and is causally associated with exposure to asbestos. Because of its aggressiveness and resistance to therapies, MPM prognosis is extremely poor and the 5-year survival rate is approximately 10%. Despite its poor effectiveness, chemotherapy with cisplatin and pemetrexed has long remained the standard-of-care for upfront treatment with no second line therapy available. Recently, the approval of ipilimumab (anti-CTLA-4) plus nivolumab (anti-PD-1) for the first-line treatment of unresectable MPM has marked a significant milestone, in particular for the non-epithelioid MPM subtype...
