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Computational Methods for Multi-Omics Data Analysis in Cancer Precision Medicine
Cancer is a complex and heterogeneous disease often caused by different alterations. The development of human cancer is due to the accumulation of genetic and epigenetic modifications that could affect the structure and function of the genome. High-throughput methods (e.g., microarray and next-generation sequencing) can investigate a tumor at multiple levels: i) DNA with genome-wide association studies (GWAS), ii) epigenetic modifications such as DNA methylation, histone changes and microRNAs (miRNAs) iii) mRNA. The availability of public datasets from different multi-omics data has been growing rapidly and could facilitate better knowledge of the biological processes of cancer. Computational approaches are essential for the analysis of big data and the identification of potential biomarkers for early and differential diagnosis, and prognosis.
Molecular Biology of Cancer
Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.
Next Generation Sequencing and Sequence Assembly
The goal of this book is to introduce the biological and technical aspects of next generation sequencing methods, as well as algorithms to assemble these sequences into whole genomes. The book is organized into two parts; part 1 introduces NGS methods and part 2 reviews assembly algorithms and gives a good insight to these methods for readers new to the field. Gathering information, about sequencing and assembly methods together, helps both biologists and computer scientists to get a clear idea about the field. Chapters will include information about new sequencing technologies such as ChIp-seq, ChIp-chip, and De Novo sequence assembly.
Coronavirus Disease - COVID-19
In December 2019, the world witnessed the occurrence of a new coronavirus to humanity. The disease spread quickly and became known as a pandemic globally, affecting both society and the health care system, both the elderly and young groups of people, and both the men’s and women’s groups. It was a universal challenge that immediately caused a surge in scientific research. Be a part of a world rising in fighting against the pandemic, the Coronavirus Disease - COVID-19 was depicted in the early days of the pandemic, but updated by more than 200 scientists and clinicians to include many facets of this new infectious pandemic, including i, characteristics, ecology, and evolution of coronavir...
Foodborne Disease and Public Health
The Institute of Medicine's Food and Nutrition Board and the National Research Council's Policy and Global Affairs Division convened a workshop in Washington, D.C., entitled Foodborne Disease and Public Health: An Iranian-American Workshop. The overall goals of this workshop were to facilitate the exchange of ideas about foodborne disease and public health and to promote further collaboration among Americans and Iranians on this topic of mutual interest. Experts invited to participate in this workshop addressed a variety of topics, ranging from the surveillance of outbreaks of foodborne illness to approaches to medical training in the Iranian and U.S. educational systems. The workshop was part of a series of cooperative efforts between the United States and Iran as the two countries have collaborated in the past on similar projects relating to foodborne disease.
