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This collection of selected chapters offers a comprehensive overview of state-of-the-art mathematical methods and tools for modeling and analyzing cancer phenomena. Topics covered include stochastic evolutionary models of cancer initiation and progression, tumor cords and their response to anticancer agents, and immune competition in tumor progression and prevention. The complexity of modeling living matter requires the development of new mathematical methods and ideas. This volume, written by first-rate researchers in the field of mathematical biology, is one of the first steps in that direction.
This book deals with analytic problems related to some developments and generalizations of the Boltzmann equation toward the modeling and qualitative analysis of large systems that are of interest in applied sciences. These generalizations are documented in the various surveys edited by Bellomo and Pulvirenti with reference to models of granular media, traffic flow, mathematical biology, communication networks, and coagulation models.The above literature motivates applied mathematicians to study the Cauchy problem and to develop an asymptotic analysis for models regarded as developments of the Boltzmann equation. This book aims to initiate the research plan by the analyzing afore mentioned a...
Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell contacts are established according to the nature of adhesion molecules that are expressed on the cell surface. The identifica tion of several families of adhesion molecules, well conserved throughout evolu tion, has been the basis of a considerable amount of work over the past 20 years that contributed to establish functions of cell adhesion in almost all organs. Nowadays, cell adhesion molecules are not just considered as cellular glue but are thought to play critical roles in cell signaling. Their ability to influence cell proliferation, mi gration, or differentiation depend...
Developmental biology and tumour growth are two important areas of current research where mathematics increasingly provides powerful new techniques and insights. The unfolding complexity of living structures from egg to embryo gives rise to a number of difficult quantitative problems that are ripe for mathematical models and analysis. Understanding this early development process involves the study of pattern formation, which mathematicians view through the lens of dynamical systems. This book addresses several issues in developmental biology, including Notch signalling pathway integration and mesenchymal compartment formation. Tumour growth is one of the primary challenges of cancer research. Its study requires interdisciplinary approaches involving the close collaboration of mathematicians, biologists and physicians. The summer school addressed angiogenesis, modelling issues arising in radiotherapy, and tumour growth viewed from the individual cell and the relation to a multiphase-fluid flow picture of that process. This book is suitable for researchers, graduate students, and advanced undergraduates interested in mathematical methods of developmental biology or tumour growth.
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread globally to pandemic proportions. Although the majority of cases have asymptomatic or mild infections, a significant proportion of cases progress to severe pneumonia and acute respiratory distress syndrome requiring critical care. Opportunistic infections following severe respiratory viral infections have been recognized since the 1918 influenza pandemic. Among critically ill patients with COVID-19, secondary fungal infections caused by Aspergillus and Candida spp. are increasingly described, affecting up to 30% of COVID-19 patients requiring intensive care treatment. This collection of manuscripts focuses on fungal infections complicating COVID-19, including immunological mechanisms and pathogenesis, diagnosis, and treatment.
This book is intended as reference material for students and professors interested in air pollution modeling at the graduate level as well as researchers and professionals involved in developing and utilizing air pollution models. Current developments in air pollution modeling are explored as a series of contributions from researchers at the forefront of their field. This newest contribution on air pollution modeling and its application is focused on local, urban, regional and intercontinental modeling; emission modeling and processing; data assimilation and air quality forecasting; model assessment and evaluation; aerosol transformation. Additionally, this work also examines the relationship between air quality and human health and the effects of climate change on air quality. This work is a collection of selected papers presented at the 37th International Technical Meeting on Air Pollution Modeling and its Application, held in Hamburg, Germany, September 23-27, 2019.
The concept of resilience has arisen as a “new way of thinking”, becoming a response to both the causes and effects of ongoing global challenges. As it strongly stresses cities’ transformative potential, resilience’s final purpose is to prevent and manage unforeseen events and improve communities’ environmental and social quality. Although the resilience theory has been investigated in depth, several methodological challenges remain, mainly related to the concept’s practical sphere. As a matter of fact, resilience is commonly criticised for being too ambiguous and empty of meaning. At the same time, turning resilience into practice is not easy to do. This will arguably be one of ...
This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. ...
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This book collects the best papers presented at a recent conference organized by SIEV (Italian Society of Appraisal and Valuation) to promote the interaction between Appraisal and Valuation and other social sciences to study the effects of migration on value and social, spatial and economic systems in a multicultural city. The book consists of seventeen papers in two parts. The first part, "Values and Relational Systems in Multicultural Societies", features how social sciences--including appraisal and valuation, urban planning, philosophy, psychology, and geography--take different approaches to studying values and relationships, converging to form a unified mosaic of complementary and interconnected knowledge. The second part, "Permeability and Permanence of Values in a Contemporary Multicultural City", highlights the most crucial topics on which appraisals and models focus to interpret and represent the influence of migration on the real estate market in different urban and territorial contexts, from historical centers, small towns, to tourist cities, also taking into account sustainability, maintenance and regeneration of cities.