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Charité-Compendium Gynäkologie
Dieses Buch behandelt kompakt, anschaulich und praxisnah alle relevanten Themengebiete der Gynäkologie. Für die 3. Auflage wurden alle Kapitel durch zahlreiche Ergänzungen auf den neuesten Stand gebracht. Neu sind Kapitel zur Strahlentherapie, zur Psychosomatik, zu Varianten der Geschlechtsentwicklung (DSD) und zwei Abschnitte zu Auswirkungen der Pandemie. Neu ist auch: Für nahezu alle Eigennamen einer Erkrankung, eines Tests, einer Behandlungsoption werden die Namensgeber kurz vorgestellt. Studentinnen und Studenten sowie Ärztinnen und Ärzte in der Facharztweiterbildung finden alle prüfungsrelevanten Lerninhalte übersichtlich dargestellt. Jedes Kapitel enthält Grafiken, Merkkästchen, praktische Tipps und Definitionen.
Handbook of Foodborne Diseases
Clearly linked to consumption of foods, beverages, and drinking water that contain pathogenic microbes, toxins, or other toxic agents, foodborne diseases have undergone a remarkable change of fortune in recent decades, from once rare and insignificant malaises to headline-grabbing and deadly outbreaks. Unquestionably, several factors have combined to make this happen. These include a prevailing demand for the convenience of ready-to-eat or heat-and-eat manufactured food products that allow ready entry and survival of some robust, temperature-insensitive microorganisms; a drastic reduction in the costs of air, sea, and road transportation that has taken some pathogenic microorganisms to where...
Voltage Gated Sodium Channels
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Abdominal and Pelvic MRI
While MRI has proved itself to be an excellent diagnostic noninvasive modality for imaging of the brain, medulla, and musculoskeletal system due to its high intrinsic con trast resolution and tissue characterisation potential based on the judicious application of specific sequences, this has not been the case in the abdomen and pelvis. The reasons are the long exposure time and the lower spatial resolution, inherent to MRI. However, during recent years considerable process has been achieved in MRI of the abdominal and pelvic organs due to the development of new and more rapid imaging sequences and the routine clinical application of specific magnetic resonance contrast media. Consequently fo...
Cancer Biomarkers in Body Fluids
The ability to measure and monitor cancer biomarkers in “body fluid biopsy” should greatly impact oncologic practice. “Biomarkers in Proximal Fluids”, the third of the “Cancer Biomarkers in Body Fluids” series details cancer signatures in none or minimally circulating body fluids including saliva, sputum, bronchoalveolar lavage fluid, exhaled breath condensate, nipple aspirate fluid, gastric and pancreatic juice, stool, urine, and prostatic, peritoneal and cerebrospinal fluid. These fluids are enriched with biomarkers, especially those emanating from cells of the proximal tissue. Chapter 1 examines the global burden of cancer and the need for regional efforts at primary preventio...
The Art of Breaking Bad News Well
As Head of Oncological Surgery and the Gynecology Clinic at Berlin’s Charité Comprehensive Cancer Center, Jalid Sehouli is one of the world’s leading cancer specialists. Every day, he experiences situations in which conversations take on a life-or-death significance. Delivering bad news is one of the most difficult tasks we face in life, especially for professionals such as doctors, police, or crisis intervention personnel, yet it is rarely touched on during training. Over the course of their career, a doctor will hold conversations with around 200,000 patients and their relatives that invariably involve delivering good or bad news. Either way, existential questions will arise, and the way the news is delivered is vital: recent studies show that it has a significant impact on patients’ quality of life and the way they experience treatment. Mixing his wide-ranging professional experience with personal stories, Sehouli describes the emotions and perspectives of those who have to give and receive bad news from a broad perspective. His book can be helpful for anyone who has to deliver bad news—managers, friends, or parents.
Ovarian Cancer Biomarkers
This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.
Multivariable Model - Building
Multivariable regression models are of fundamental importance in all areas of science in which empirical data must be analyzed. This book proposes a systematic approach to building such models based on standard principles of statistical modeling. The main emphasis is on the fractional polynomial method for modeling the influence of continuous variables in a multivariable context, a topic for which there is no standard approach. Existing options range from very simple step functions to highly complex adaptive methods such as multivariate splines with many knots and penalisation. This new approach, developed in part by the authors over the last decade, is a compromise which promotes interpretable, comprehensible and transportable models.
