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Targeted Protein Degradation
This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery.
Activity-Based Protein Profiling
This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.
Doing Business in 2005
Doing Business in 2005: Obstacles to Growth is the second in a series of annual reports investigating the scope and manner of regulations that enhance business activity and those that constrain it. New quantitative indicators on business regulations and their enforcement can be compared across more than 130 countries, and over time. The indicators are used to analyze economic outcomes and identify what reforms have worked, where and why. Topics in Doing Business in 2005 include: Licensing and Inspections: Having registered a business, now what? In most countries, firms face a myriad of sector specific licenses as well as inspections to enforce compliance. The Doing Business database construc...
Proteome Informatics
Bringing together world experts to provide clear explanations of the key algorithms, workflows and analysis frameworks, Proteome Informatics will provide a detailed introduction to the main informatics topics that underpin the various LC-MS/MS protocols used for protein identification and quantitation.
Doing Business 2010
The seventh in a series of annual reports investigating the regulations that enhance business activity and those that constrain it, 'Doing Business' presents quantitative indicators on business regulations and the protection of property rights that can be compared across 183 economies--from Afghanistan to Zimbabwe--and over time. Regulations affecting 10 stages of a business's life are measured: starting a business, dealing with construction permits, employing workers, registering property, getting credit, protecting investors, paying taxes, trading across borders, enforcing contracts and closing a business. Data in 'Doing Business 2010' are current as of June 1, 2009. The indicators are used to analyze economic outcomes and identify what reforms have worked, where and why.
Doing Business 2008
Regulations affecting 10 areas of everyday business are measured: starting a business, dealing with licenses, employing workers, registering property, getting credit, protecting investors, paying taxes, trading across borders, enforcing contracts, and closing a business. 'Doing Business 2008' updates all 10 sets of indicators, ranks countries on their overall ease of doing business, and analyzes reforms to business regulation - identifying which countries are improving their business environment the most and which ones slipped. The indicators are used to analyze economic outcomes and identify what reforms have worked, where and why. 'Doing Business 2008' focuses on how complex business regulations dampen investment, growth and job creation in all businesses, and especially opportunities for women entrepreneurs.
Doing Business in 2004
A co-publication of the World Bank, International Finance Corporation and Oxford University Press
Mathematical Physics II
The charm of Mathematical Physics resides in the conceptual difficulty of understanding why the language of Mathematics is so appropriate to formulate the laws of Physics and to make precise predictions. Citing Eugene Wigner, this “unreasonable appropriateness of Mathematics in the Natural Sciences” emerged soon at the beginning of the scientific thought and was splendidly depicted by the words of Galileo: “The grand book, the Universe, is written in the language of Mathematics.” In this marriage, what Bertrand Russell called the supreme beauty, cold and austere, of Mathematics complements the supreme beauty, warm and engaging, of Physics. This book, which consists of nine articles, ...
Doing Business in 2006
This publication is the third in a series of annual reports giving a comparative analysis of business regulations and their enforcement across 155 countries and over time. Comparable data indicators are given for 10 topics: starting a business, dealing with licences, hiring and firing workers, registering property, getting credit, investment protection, paying taxes, trading across borders, enforcing contracts, and closing a business. These indicators are used to assess socio-economic outcomes including levels of unemployment and poverty, productivity, investment and corruption; and to identify which regulatory measures enhance business activity and those that work to constrain it. This is a co-publication of the World Bank and the International Finance Corporation.
Sweeney's Flight
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