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This book provides a system for rapid diagnosis and efficient management of depression, including patient education, brief supportive counseling, and medication. It also focuses on treatment with antidepressant medications, including when to initiate treatment, antidepressant pharmacology, how to select the appropriate medication, and how to manage treatment failures. The results of the STAR*D trial are reviewed in detail.
As adaptive capacities decline, and disease increases, the elderly become major consumers of drugs. Because of the special needs of older patients, physicians, geriatricians, health providers, and researchers must know how the aging process changes the pharmacokinetic and pharmacodynamic properties of drugs prescribed to the elderly. The Second Edition of this essential handbook is an up-to-date source that analyses the major drug groups, the disorders they treat, and the age-associated changes in cellular processes that affect drug action. Disorders prevalent in older people, such as Alzheimer's disease and Parkinson's disease, are examined in great detail. The book also discusses a wide range of drugs, including bronchodilators for asthma, nonsteroid anti-inflammatory drugs for arthritis, antibiotics, and treatments for cardiovascular disease, cancer, and mental disorders. The handbook also provides insight into future research problems dealing with the expanding aging population, their drug usage, and increasing adverse drug reactions.
Frontiers in Catecholamine Research is a collection of papers presented at the Third International Catecholamine Symposium, held at the University of Strasbourg, Strasbourg, France, on May 20-25, 1973. This book is organized into nine parts encompassing 205 chapters. The text begins with a discussion on clinically and experimentally used drugs that have been developed or whose mechanism of action has been clarified through monoamine research. Parts II and III deal with enzymes related to catecholamine studies, their properties, regulation, genetics, mechanism of action, and localization. Parts IV and V examine the concepts of synaptic dynamics of brain regulators and the isolation, characterization, methods of analysis, and mechanism of action of catecholamines. Part VI focuses on the complexities that surround the extrapolation of catecholamine function into the realms of electrophysiology and behavior. Part VII discusses the metabolism, behavioral, neurological, and physiological effects of amphetamine and other drugs of abuse. The concluding parts describe the role of catecholamine and its metabolism in neurologic diseases, such as schizophrenia.
A comprehensive review of the current status of antidepressants - how we arrived at this point in their evolution and where we are going in both the near and the long term. It employs both a scientific and historical approach to accomplish these goals. This volume is intended for practitioners who use antidepressants on a daily basis in their practice as well as for the student and researcher. Each will find that it provides a comprehensive and logical approach to this important group of medications. This book is being published as we mark the end of the first 50 years of the modern antidepressant era.
The sixth volume of The History of Neuroscience in Autobiography is a collection of autobiographical essays by notable senior scientists who discuss the major events that shaped their discoveries and their influences, as well as the people who inspired them and helped shape their careers as neuroscientists. Each entry also includes a complete CV so that the interested reader may see their rise through the ranks as they achieved some of the highest honors in neuroscience.