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This latest volume in the Harvey Lectures Series reflects "the evolution of physiology and physiological chemistry into biochemistry and the development of molecular biology from the roots of bacteriology and biochemistry" in the 20th and 21st centuries. This lecture series, collected and published annually, provides a series of distinguished lectures in the life sciences by world-renowned scientists in all areas of biomedicine. These lectures occur in New York City throughout the course of each academic year.
The Harvey Society was founded in 1905 by thirteen New York scientists and physicians with the purpose of forging a "closer relationship between the purely practical side of medicine and the results of laboratory investigation." The Society distributes scientific knowledge in selected areas of anatomy, physiology, pathology, bacteriology, pharmacology, and physiological and pathological chemistry through public lectures, which are published annually. Series 94, 1998-1999 covers themes in neurogenetic studies, the role of tyrosine phosphorylation in cell growth and disease, the biology of the epidermis and its appendages, and the phenotypic diversity of monogenic disease.
On March 27, 1990, the National Cancer Institute sponsored a workshop on the epidemiology of multiple myeloma, held at the National Institutes of Health. This book comprises articles prepared by participants in this work shop. Discussed in these papers are: the descriptive and analytic epidemi ology, differences in risk factors between blacks and whites, monoclonal gammopathies and their progression, and hypotheses regarding the etiology and pathogenesis of multiple myeloma. Several epidemiologic research areas received particular attention during this workshop, and are reviewed in detail in this volume. There have been striking increases in the incidence of multiple myeloma over the past th...
Provides information concerning research grants and contracts supported by the National Cancer Institute.
Until recently, understanding of the lymphomas was limited and largely descriptive. Attention has been focused, for the most part, upon morphological issues and clinical matters. Although useful, this approach has many shortcomings. The true cytoidentity of primary neoplastic cells was not established by these methods, nor could their clonal nature be recognized. The more overt changes in immunological function, such as monoclonal gammopathies and immunodeficiencies, were appre ciated as important components of these diseases. However, subtle immunological perturbations were not recognized. Furthermore, associations were not established between the lymphoreticular neoplasms on the one hand a...
Students and house staff officers are lucky when one of their professors takes the time to discuss with them how he/she tells a bad diagnosis to a new patient. This is how I advise them to handle it: 'Take a chair or sit on the edge of the bed if need be and touch a hand. That will comfort the patient. And don't think for a minute that men do not appreciate that gesture; they do. Unless the patient decides differently, it is better when the spouse, a close member of the family or a friend is present. Remember that after you leave the room, it will be awfully lonely for the patient. Tell the bad news, but immediately hold out a few rays of hope to grasp. And be prepared to answer the questions that will follow, not once but several times because most patients do not remember what you told them. You will be amazed how the well-informed patients accept the worst diagnosis and how grateful they are that you took the time to sit with them. Answer all questions and remember, the informed patient becomes your best patient. And no question is a dumb question.'
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