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Organoid Technology for Disease Modelling and Personalised Treatment provides a comprehensive overview of current knowledge of the organoid as a human-organ-in-a-dish, a powerful new technology for studying fundamental aspects of human organ development and disease progression in the search for drugs for personalised treatment. This preclinical tool is extensively being utilised as a model for studying human diseases in a dish, which is critical for accurate predictive modelling in precision medicine. The chapters in this book introduces readers to the numerous applications of organoids in various fields of study, as well as ethical considerations associated with organoids. In stem cell biol...
When Lou Brandon retires as the only constable of a small Manitoba town, his life takes on a comfortable but aimless routine. That changes when he slowly becomes friends with the new Catholic priest, Peter Wilson. As the two struggle with life, unlikely circumstances bring them together to investigate a murder long thought solved. Their friendship gives them the space to question the burdens they carry and how these have limited their lives. But examining life, particularly when it has not been lived honestly, is much easier said than done. Learning to face their truths gives them the opportunity to grow, but comes with risks of failure they may be unwilling to face. As Brandon and Wilson draw closer to identifying the real murderer, the uncomfortable relationship between the local Indigenous and non-Indigenous communities threatens to derail their investigation completely. Will they be able to find justice for the victim and reconciliation to themselves before it’s too late?
This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves seq...
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Pericytes were originally discovered and named more than hundred years ago as contractile cells around the blood vessel endothelial cells. Due to the lack of exclusive markers, pericytes are now defined by a combination of location, morphology and gene expression. Pericytes are attracting increasing attention as important regulators during development and during normal and disturbed organ function. In recent years, remarkable progress has been made in the identification and characterization of pericytes subpopulations and their amazing functions using state-of-art techniques. These advantages facilitated identification of molecular basis of interaction between these cells with several other ...
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