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Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and...
A classic fictional chronicle of life on the open trail, THE LOG OF A COWBOY has long been considered the best and most reliable account of real cowboy life ever written. In the years following the Civil War, sixteen-year-old Andy Adams left his home in the San Antonio Valley and took to the range. Here he charts his first journey as a bona fide cowboy, from south Texas to Montana along the western trail. Guided by his plainspoken, sure-saddled voice and the living, breathing feel of firsthand experience on every page, we relive dusty cattle drives, perilous river crossings, honor-based gunfights, and narrow escapes from buffalo stampedes, not to mention tall tales passed around the campfire and such unforgettable characters as Bull Durham and Bill Blades.
The family into which Mozart was born has never received a rigorous contextual study which does justice to the complexity of its relationships or to its interactions with colleagues, friends, and neighbours in Mozarts native city, Salzburg. Most biographies of Mozart have undervalued the manypassages in the rich family correspondence which do not bear directly on him. This book draws on the neglected material, most of which has never been translated into English. At the heart of the work is a detailed examination of the letters, supplemented by little-known archival material from thepapers of the Berchtold family, into which Mozarts sister Nannerl married. Additional information concerning S...
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This book was originally published in 1954. Grahame Clark's excavations at Star Carr from 1949 to 1951 have long been regarded as a model of how archaeological investigation should be conducted. In addition to this, the importance of the site itself, the first early mesolithic site in Europe from which a full complement of bone, antler, wood and other organic material was recovered alongside the flint industry, has established for this report on the excavations a permanent place in all archaeological libraries. The book is now reissued.
This text offers an intervention into the debate between communitarianism and liberalism. It argues for a theory of "contexts of justice" that leads beyond the confines of the debate as it has been understood and posits the possibility of a new conception of social and political justice.
Tumour Angiogenesis is the first comprehensive book to cover all areas of this rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases,extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis - these include vascular endothelial growth factor, the basic fibroblast growth factor family, transforminggrowth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumour microvessel density and thetherapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.