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Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.
Nanotechnology: Advances and Real-Life Applications offers a comprehensive reference text about advanced concepts and applications in the field of nanotechnology. The text – written by researchers practicing in the field – presents a detailed discussion of key concepts including nanomaterials and their synthesis, fabrication and characterization of nanomaterials, carbon-based nanomaterials, nano-bio interface, and nanoelectronics. The applications of nanotechnology in the fields of renewable energy, medicine and agriculture are each covered in a dedicated chapter. The text will be invaluable for senior undergraduate and graduate students in the fields of electrical engineering, electronics engineering, nanotechnology and nanoscience. Dr. Cherry Bhargava is an Associate Professor and Head, VLSI domain, at the School of Electrical and Electronics Engineering of Lovely Professional University, Jalandhar, India. Dr. Amit Sachdeva is an Associate Professor at Lovely Professional University, Jalandhar, India.
This book, Food Product Optimization for Quality and Safety Control: Process, Monitoring, and Standards discusses food quality and safety standards that are critically important for both developed and developing economies, where consumer safety is among the primary issues to be considered in food supply chain management.
This detailed bibliographical dictionary constitutes a virtual encyclopaedia of the Spanish School, covering artists born in Spain as well as those who worked chiefly in Spain. 16,000 years of Spanish art are documented with consideration paid to each artist's birth and death dates; medium; and bibliographical references. This three-volume work lists approximately 10,000 painters, sculptors, draftsmen, printmakers, architects, and applied artists.
This book examines the lives, careers, and publications of a group of Spanish Renaissance surgeons as exemplars of both the surgical renaissance occurring across Europe and of the unique context of Spain. In the sixteenth century, European surgeons forged new identities as learned experts who combined university medical degrees with manual skills and practical experience. No longer merely apprentice-trained craftsmen engaged only with healing the exterior wounds and rashes of the body, these learned surgeons actively engaged with the epistemic shifts of the sixteenth century, including new forms of knowledge construction, based in empiricism, and knowledge circulation, based in printing. The...
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