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ATP-gated P2X receptors in health and disease
Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research...
Textbook of Ion Channels Volume II
The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging refer- ence source on ion channels for students, instructors and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells; mediate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excit- able tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well...
Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the grow...
L'Origine des consciences
L’hypothèse développée dans cet ouvrage, « le corps est conscience », se fonde sur les origines conjointes du corps et de la conscience, les deux ayant évolué ensemble sur 15 milliards d’années. L’anatomie et la conscience humaine reflètent un zoo : mammifères, singes, mollusques, poissons, reptiles, insectes, bactéries. Dans ce contexte évolutif, le corps et la conscience de l’enfant ne sont pas des adultes miniatures, mais des êtres en maturation à partir de structures originelles évoquées dans cet ouvrage. Ainsi, la psyché humaine émane d’une dimension sociologique, à savoir une évolution de la famille primitive à partir des mammifères. Les différentes facettes de la conscience humaine sont évoquées par la mythologie grecque au travers de chimères homme-animal. À partir de mon expérience d’ostéopathe explicitée dans cet ouvrage, l’existence de « fossiles de conscience » me semble être des troubles psychiques et de maladies psychosomatiques (dépression, épilepsie) qui révèlent un corps-conscience puzzle d’espèces : la part poisson, insecte, reptile entre autres chez les humains.
Regimes of Mobility
Mobility studies emerged from a postmodern moment in which global ‘flows’ of capital, people and objects were increasingly noted and celebrated. Within this new scholarship, categories of migrancy are all seen through the same analytical lens. This book builds on, as well as critiques, past and present studies of mobility. In so doing, it challenges conceptual orientations built on binaries of difference that have impeded analyses of the interrelationship between mobility and stasis. These include methodological nationalism, which counterpoises concepts of internal and international movement and native and foreigner, and consequently normalises stasis. Instead, the book proposes a ‘reg...
Female Pioneers from Ancient Egypt and the Middle East
This book explores the contributions of Eastern female pioneers in science, politics and arts from Ancient Egypt to modern times, and discusses the possible psychological and social impact of this knowledge on today’s gender role in Eastern and Western Societies. Based on psychological studies on social learning, the book argues that profound knowledge of the historical contributions of Eastern female pioneers in science, politics and arts can improve today’s gender roles in Middle Eastern countries and inspire young women living in Western Societies with Eastern migration background. Spanning disciplines such as Natural sciences, Neuroscience, Psychology, Sociology, Islamic Theology, History and Arts, and including contributions from diverse geographical regions across the world, this book provides an elaborate review of the gender role of women in Ancient Egypt and the Middle East, outlining their prominence and influence and discusses the possible psychological and social impact of this knowledge on today’s gender roles.
