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Histone Deacetylases
A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.
Integrated Pest and Disease Management in Greenhouse Crops
This book represents a new, completely updated, version of a book edited by two of the current editors, published with Springer in 1999. It covers pest and disease management of greenhouse crops, providing readers the basic strategies and tactics of integrated control together with its implementation in practice, with case studies with selected crops. The diversity of editors and authors provides readers a complete picture of the world situation of IPM in greenhouse crops.
Chromatin and Chromatin Remodeling Enzymes
DNA in the nucleus of plant and animal cells is stored in the form of chromatin. Chromatin and the chromatin remodelling enzymes play an important role in gene transcription. Genetic assays of chromatin modification and remodeling Histone modifying enzymes ATP-dependent chromatin remodeling enzymes
Reversible Protein Acetylation
A comprehensive review of recent work on chromatin and non-histone proteins, this book arises from the interactions of a multidisciplinary group of scientists involved in the study of acetylation. This area of research opens up new and exciting possibilities for drug design, and so the final chapters in the book examine some of the potential applications in the treatment of various diseases.
The Biology of Death
"Everyone dies, and so, we naturally associate death with the end of an individual life. However, life is much more complicated, and death is actually interwoven into biology at many levels. Normal development and life could not exist without carefully regulated death of certain cells and as one defense against disease. Other cells wear out and die and must be replaced regularly. On a larger scale, death has influenced the direction of entire species. In fact, death has shaped all life through the cycle of life and death, throughout time, and in normal development. It affects our cells, our development, and our life"--
Function and Regulation of the Human NAD+-dependent Protein Deacetylase SIRT2
Silent information regulator 2 (Sir2) proteins, or sirtuins, are NAD +-dependent protein deacetylases present in organisms ranging from bacteria to humans. In eukaryotes, sirtuins function in regulation of transcriptional repression, recombination, cell cycle division, DNA damage repair, and the molecular mechanisms governing aging. In addition to a conserved catalytic domain, sirtuins contain variable amino- and carboxy-terminal extensions that are suspected to regulate their subcellular localization and catalytic activity.
Viruses and Virus Diseases of Vegetables in the Mediterranean Basin
This volume of Advances in Virus Research focuses on mycoviruses. The authors and reviews represent the most current and cutting-edge research in the field. A broad range of research is presented from research experts. Contributions from leading authorities Informs and updates on all the latest developments in the field
Scientific Directory and Annual Bibliography
Each issue lists papers published during the preceding year.
Epigenetics in Cardiac Disease
This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.
The Death of Death
Is death inevitable? Until now, the history of mankind has been marked by this fatal fact. Religions, borders and progress are born from an ancient fear of death, comfort from this fear man often found only in religious paradigms. But according to José Luis Cordeiro and David Wood, the incontrovertible fact of death is no longer an absolute certainty - science and technology are preparing to tear down the final frontier: that of immortality. This accessible book provides insight into recent exponential advances in artificial intelligence, tissue regeneration, stem cell treatment, organ printing, cryopreservation, and genetic therapies that, for the first time in human history, offer a reali...
