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Adaptive Treatment Strategies in Practice: Planning Trials and Analyzing Data for Personalized Medicine
Personalized medicine is a medical paradigm that emphasizes systematic use of individual patient information to optimize that patient's health care, particularly in managing chronic conditions and treating cancer. In the statistical literature, sequential decision making is known as an adaptive treatment strategy (ATS) or a dynamic treatment regime (DTR). The field of DTRs emerges at the interface of statistics, machine learning, and biomedical science to provide a data-driven framework for precision medicine.? The authors provide a learning-by-seeing approach to the development of ATSs, aimed at a broad audience of health researchers. All estimation procedures used are described in sufficie...
Statistical Methods for Dynamic Treatment Regimes
Statistical Methods for Dynamic Treatment Regimes shares state of the art of statistical methods developed to address questions of estimation and inference for dynamic treatment regimes, a branch of personalized medicine. This volume demonstrates these methods with their conceptual underpinnings and illustration through analysis of real and simulated data. These methods are immediately applicable to the practice of personalized medicine, which is a medical paradigm that emphasizes the systematic use of individual patient information to optimize patient health care. This is the first single source to provide an overview of methodology and results gathered from journals, proceedings, and techn...
Handbook of Statistical Methods for Precision Medicine
The statistical study and development of analytic methodology for individualization of treatments is no longer in its infancy. Many methods of study design, estimation, and inference exist, and the tools available to the analyst are ever growing. This handbook introduces the foundations of modern statistical approaches to precision medicine, bridging key ideas to active lines of current research in precision medicine. The contributions in this handbook vary in their level of assumed statistical knowledge; all contributions are accessible to a wide readership of statisticians and computer scientists including graduate students and new researchers in the area. Many contributions, particularly ...
Case Studies in Innovative Clinical Trials
Drug development is a strictly regulated area. As such, marketing approval of a new drug depends heavily, if not exclusively, on evidence generated from clinical trials. Drug development has seen tremendous innovation in science and technology that has revolutionized the treatment of some diseases. And yet, the statistical design and practical conduct of the clinical trials used to test new therapeutics for safety and efficacy have changed very little over the decades. Our approach to clinical trials is steeped in convention and tradition. The large, fixed, randomized controlled trial methods that have been the gold standard are well understood and expected by many trial stakeholders. Howeve...
Opening Up: Capital Flows and Financial Sector Dynamics in Low-Income Developing Countries
Over the past two decades, many low-income developing countries have substantially increased openness towards external financing and have received large capital inflows. Using bank-level micro data, this paper finds that capital inflows have been associated with financial deepening through increases in bank loans, deposits, and wholesale funding. Domestic banks increase loans more than foreign banks. There are only modest signs of a build-up in financial vulnerabilities. Causality is examined through an instrumental variable approach and an augmented inverse-probability weighting estimator. These approaches indicate only limited evidence for global push effects, pointing towards the importance of domestic pull factors.
Statistical Methods in Health Disparity Research
A health disparity refers to a higher burden of illness, injury, disability, or mortality experienced by one group relative to others attributable to multiple factors including socioeconomic status, environmental factors, insufficient access to health care, individual risk factors, and behaviors and inequalities in education. These disparities may be due to many factors including age, income, and race. Statistical Methods in Health Disparity Research will focus on their estimation, ranging from classical approaches including the quantification of a disparity, to more formal modeling, to modern approaches involving more flexible computational approaches. Features: Presents an overview of meth...
Honduras: The impact of covid-19 and policy implications: Second report
Due to the global pandemic generated by COVID-19 the government of Honduras declared a “state of emergency” in February (“Estado de Emergencia en el Territorio Nacional a través del Decreto Ejecu-tivo Número PCM- 005-2020, 10 de febrero 2020). The country suffered the first confirmed COVID-19 case on March 12th, 2020. The first death was registered on March 26, 2020. This document updates a previous report (Díaz Bonilla, Laborde, and Piñeiro, 2021) on the impact of the COVID-19 pandemic on food systems in Honduras. First, it brings up to date the evolution of the pandemic, using different indicators. Second, it summarizes the main policy responses, costs, and fi-nancing. Third, it updates the evolution of key variables up to the time of this writing (June 2021). Fourth, there is a more detailed analysis of the evolution of some food value chains that are central for food consumption in Honduras. Fifth, main results for 2021 and 2022 of previous modeling work are briefly presented. A final section discusses policy considerations in light of the updated analysis.
Handbook of Matching and Weighting Adjustments for Causal Inference
An observational study infers the effects caused by a treatment, policy, program, intervention, or exposure in a context in which randomized experimentation is unethical or impractical. One task in an observational study is to adjust for visible pretreatment differences between the treated and control groups. Multivariate matching and weighting are two modern forms of adjustment. This handbook provides a comprehensive survey of the most recent methods of adjustment by matching, weighting, machine learning and their combinations. Three additional chapters introduce the steps from association to causation that follow after adjustments are complete. When used alone, matching and weighting do not use outcome information, so they are part of the design of an observational study. When used in conjunction with models for the outcome, matching and weighting may enhance the robustness of model-based adjustments. The book is for researchers in medicine, economics, public health, psychology, epidemiology, public program evaluation, and statistics who examine evidence of the effects on human beings of treatments, policies or exposures.
Guatemala: The impact of COVID-19 and policy implications: Second report
Amid concerns about the beginning of the COVID-19 pandemic, Guatemala, in January 2020 decreed travel bans from China, which were later expanded to other countries. The country had the first confirmed COVID-19 case on March 13 and the first death on March 15. Some days before that, on March 5, the government had declared a “state of calamity” (Declaración del Estado de Calamidad Pública - Decreto Gubernativo Número 5-2020), which allowed the government to limit some activities,1 and to take different actions2 to protect the health and safety of all persons in Guatemala. This document updates a previous report (Díaz Bonilla, Laborde and Piñeiro, 2021) on the impact of the COVID-19 pa...
