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Microbial Host-interaction
Most indigenous microbes occur in the intestinal tract, and their interactions with the host are largely unknown. Current understanding of host-microbe interactions links early microbial contact to the origin of disease, a theory that has its roots in the hygiene hypothesis. Modern life style appears to deprive the infant of conditions that provide adequate anti-inflammatory or tolerogenic stimuli upon antigen encounter. Thus, maturational signals from the environment and the diet are insufficient to adequately shape the immune system. This publication deals with the relationship between the gut microbiota as well as altered pattern of early microbial contact and the origin of human disease. New aspects of the original hygiene hypothesis are discussed in relation to disorders spanning from allergy and autoimmunity to obesity.The results presented suggest that all these disorders may be linked to aberrant antigen absorption and immune responses associated with dysfunction of mucosal defense. Researchers, clinicians and students interested in the interaction of the host with indigenous gut bacteria and the consequences for human health will find this publication of utmost interest.
Intestinal Microbiome: Functional Aspects in Health and Disease
The intestinal microbiome is especially important during the first thousand days of life. Exposure to microbes in utero significantly impacts fetal development, in part through epigenetic processes and in part through hormonal influences which cause a change in the mother's intestinal microbiome. The nature of delivery and perinatal antibiotic treatment, as well as diet (especially in the postpartum period), can also influence initial microbial colonization and the development of appropriate intestinal defense mechanisms. These, in turn, can affect the expression of allergy, autoimmune disease, and brain function, among other things, later in life. The first part of this publication focuses on the development of the human microbiome in utero and the importance of normal colonization of the newborn gut in immune development and disease prevention. The second section deals with the normal development of gut microbiota and with clinical conditions associated with dysbiosis. The final chapters cover various aspects of human milk evolution and oligosaccharides.
Prebiotics and Probiotics Science and Technology
A comprehensive overview on the advances in the field, this volume presents the science underpinning the probiotic and prebiotic effects, the latest in vivo studies, the technological issues in the development and manufacture of these types of products, and the regulatory issues involved. It will be a useful reference for both scientists and technologists working in academic and governmental institutes, and the industry.
Allergic Diseases and the Environment
During the last two decades the increase in allergic diseases in children, such as atopic dermatitis and asthma, has been drastic. However, this is not true for the entire world: the incidence of allergies in children has risen only in developed countries. The observation of this socio-geographic discrepancy has led to careful study of the environmental differences that exist between the diverse settings in which children are born and has resulted in the so-called 'hygiene hypothesis': the 'sterility' of modern hospitals and birth places in the developed world might lead to a lack of microbial stimulation required for the development of a balanced mucosal immune response, including expansion of T-helper (Th) cell subsets that can mediate immune responses. Therefore, this workshop was held to consider in depth the environmental factors that influence the changing pattern of worldwide childhood allergy. This publication is a valuable source of knowledge and update for nutritionists, pediatricians, immunologists, microbiologists, as well as professionals concerned with preventive medicine.
Clinical Applications of Probiotics in Gastroenterology: Questions and Answers, An Issue of Gastroenterology Clinics
The authors in this issue will provide state-of-the-art reviews on the use of probiotics in care of the gastroenterologic system. Articles are devoted to probiotics as treatment for IBD, chronic diarrhea, C. difficile colitis, functional bowel disease, allergic disorders, necrotizing enterocolitis, and obesity. Other articles examine the safety of probiotics, fecal biotherapy, and molecular assessment of intestinal microflora.
GI Microbiota and Regulation of the Immune System
This book covers current trends in the investigation of GI microbiota. It examines the relationship between the microbiota and the immune system from a variety of angles.
Dr. Colbert's Health Zone Essentials
FROM NEW YORK TIMES BEST SELLING AUTHOR Effective protocols for restored health and longevity! After reading this book, you will have the knowledge and the understanding to create clean, healthy habits to guide your lifestyle so you can prevent and reverse a life of illness. Don Colbert, MD, the acclaimed author of multiple New York Times best-selling books, curates the most effective protocols from his popular Zone series—Dr. Colbert’s Healthy Brain Zone, Dr. Colbert’s Fasting Zone, Dr. Colbert’s Hormone Health Zone, and Dr. Colbert’s Healthy Gut Zone—to present his most comprehensive guide for lasting health and wellness. Dr. Colbert’s Health Zone Essentials leads readers int...
Parental Obesity: Intergenerational Programming and Consequences
In this book, leading figures in the field of Developmental Origins of Health and Disease provide up-to-date information from human clinical trials, cohorts, and animal physiology experiments to reveal the interdependence between parental obesity and health of the offspring. Obesity of the mother and father produces obesity in their offspring, so we are caught up in an intergenerational cycle, which means that even our children’s future health is in peril. This book gives a timely and much-needed synthesis of the mechanisms, potential targets of future interventions, and the challenges that need to be overcome in order to break the intergenerational cycle of obesity. This has profound implications for the way in which scientific, clinical and health policy activities are to be directed in order to combat the so-called epidemic of obesity, as well as diabetes, cancer and cardiovascular disease. The book will be of interest to students, clinicians, researchers and health policy makers who are either seeking an introduction to the area of Developmental Origins of Health and Disease or have a specific interest in the pathogenesis of obesity.
What the Bleep $#@! Can I Eat?
What the bleep $#@! can I eat? is the definitive guide to adopt healthy eating habits to correct health problems such as gastrointestinal problems, food allergies, celiac disease, diabetes, high cholesterol, hypertension, obesity, aging, cancer risk and more!
