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Biophysicist James Till and cellular biologist Ernest McCulloch changed the world when they discovered stem cells in the 1960s. Through informative images and an accessible narrative, readers will learn how differences in their upbringings, fields of study, and even personalities helped their groundbreaking work. In this extensive look at the world of stem cells, then and now, students will experience the excitement of the Canadian duo's discovery and the impact it had, as well as learn the intricacies of the scientists' laboratory work and its long-reaching effects.
In proving the existence of stem cells, Ernest Armstrong McCulloch and James Edgar Till formed the most important partnership in Canadian medical research since Frederick Banting and Charles Best, the discoverers of insulin. Together, Till and McCulloch instructed, influenced, and inspired successive generations of researchers who have used their findings to make huge advances against disease. Thousands of people who would have died from leukemia and immunological disorders now owe their lives to therapies developed from their discoveries. Despite their accomplishments, Till and McCulloch remain largely unknown, and until now, their story has remained untold. Dreams and Due Diligence vividly chronicles the work of two researchers who made medical history – two men who possessed exactly the right complementary talents to achieve greatness and win nearly every award available in medical research. Bringing their legacy to life for the first time, Joe Sornberger provides a dramatic account of the development of stem cell research, one of today's most ground-breaking medical scientific fields.
In The Ontario Cancer Institute Ernest McCulloch discusses how the institute, dedicated to the goal of reducing the burden of cancer, continuously strove for excellence and shows how both original and collaborative work were encouraged within a supportive environment. To achieve this goal the institute divided its operation into four strands: two of the strands were the research areas – the study of advanced radiation therapy and biology, which worked separatively but cooperatively; a third was patient care; and the fourth element was leadership, provided by the clinical chiefs, the heads of the research divisions, and the administration, in particular the institute's first administrator, ...
This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells.
This book brings together in one volume fifteen discoveries that have had a major impact upon medical science and the practice of medicine but where the scientists involved have not been awarded a Nobel Prize. Its aim is to publicize the achievements of these lesser-known heroes of our time and thereby inform and entertain the reader, whether medical student, professor or scientifically-minded layman.
The Routledge International Encyclopedia of Education is a unique and major resource for the field of education. It is a comprehensive, single-volume work, arranged alphabetically and comprising around 600 entries. The entries range from definitions of key educational concepts and terms to biographies of key educators and specially written substantial essays on major educational topics. The volume includes authoritative and critical commentary on historical and contemporary themes; examinations of continuities, changes and emerging issues; and discussions of the educational traditions and features of major countries and continents. The following special features are also included: Unrivalled...
Featuring close readings of commonly studied texts, this book takes students of Children's Literature through the key works, their contexts and critical and popular afterlives.
Cheryl Wells provides an edited and fully annotated collection of Wafer's diary entries during the war, his letters home, and the memoirs he wrote after returning to Canada. Wafer's writings are a fascinating and deeply personal account of the actions, duties, feelings, and perceptions of a noncombatant who experienced the thick of battle and its grave consequences.
Fifteen-year-old Raim lives in a world where you tie a knot for every promise that you make. Break that promise and you are scarred for life, and cast out into the desert. Raim has worn a simple knot around his wrist for as long as he can remember. No one knows where it came from, and which promise of his it symbolises, but he barely thinks about it at all - not since becoming the most promising young fighter ever to train for the elite Yun guard. But on the most important day of his life, when he binds his life to his best friend (and future king) Khareh, the string bursts into flames and sears a dark mark into his skin. Scarred now as an oath-breaker, Raim has two options: run, or be killed.
This book collects articles on the biology of hematopoietic stem cells during embryonic development, reporting on fly, fish, avian and mammalian models. The text invites a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing conserved trends in development. The book reviews current knowledge on human hematopoietic development and discusses recent breakthroughs of relevance to both researchers and clinicians.