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The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance
The focus of this eBook is to bring new insights into central immune tolerance. To fulfill that, much has been discussed about the master in the regulation of tolerance, the autoimmune regulator (Aire) gene the main thymus cell type that expresses this gene, the medullary thymic epithelial cells (mTECs). It includes one Editorial and 12 other excellent contributions in the format of mini reviews or original research papers covering one or more of these aspects: promiscuous gene expression (PGE), epigenetics, miRNAs, association of the Aire gene and miRNAs, thymocyte–TEC interaction, coxsackievirus and type 1 diabetes, exosomes in the thymus, thymic crosstalk, thymic B cells, T cell develop...
Pharmaceutical Packaging Technology
Pharmaceutical packaging requires a greater knowledge of materials and a greater intensity of testing than most other packed products, not to mention a sound knowledge of pharmaceutical products and an understanding of regulatory requirements. Structured to meet the needs of the global market, this volume provides an assessment of a wide range of issues. It covers the entire supply chain from conversion of raw materials into packaging materials and then assembled into product packs. Integrating information from many drug delivery systems, the author discusses testing and evaluation and emphasizes traceability and the need to for additional safeguards.
Vaccinia Virus and Poxvirology
Since the first edition of Vaccinia Virus and Poxvirology: Methods and Protocols was published, a number of important events related to poxvirology have occurred, such as FDA approval of a culture-based live smallpox vaccine and the vaccination of large numbers of U.S. military and relatively large numbers of U.S. civilians. Novel anti-poxvirus therapeutics have been developed and have been used in emergency settings. The second edition of Vaccinia Virus and Poxvirology expands upon the previous edition with entirely new sets of protocols. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Vaccinia Virus and Poxvirology: Methods and Protocols, Second Edition seeks to aid scientists in continuing to study poxviruses using new tools and approaches.
Steps under Water
Steps Under Water is a novel drawn from Alicia Kozameh’s experiences as a political prisoner in Argentina during the "Dirty War" of the 1970s. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1997. Steps Under Water is a novel drawn from Alicia Kozameh’s experiences as a political prisoner in Argentina during the "Dirty War" of the 1970s. This title is part of UC Press's Voices Revived program, which commemorates University of Cali
Natural Healing in Gynecology
Suggests herbal treatments for menopause, vaginal infections, and menstrual ailments, and explains why natural healding is superior to modern medical practices
Pressure Ulcer Research
Presents both current and future aspects of diagnosis and treatment. Presents evidence-based knowledge of pressure ulcer aetiology. Contains over 90 illustrations. Explores the possiblities of tissue repair using new tissue engineering strategies.
On Assistance to the Poor
Sixteenth-century humanist Juan Luis Vives sought to find ways to alleviate the sufferings of the poor of Bruges, dealing with problems and presenting solutions that sound remarkably familiar to twentieth-century urban ears.
Thymus Transcriptome and Cell Biology
This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases.
Clostridial Diseases of Animals
Clostridial Diseases of Animals is the first book to focus on clostridial diseases in domestic and wild animals, offering a comprehensive reference on these common diseases. Provides a single resource for all aspects of clostridial diseases Presents current, comprehensive information with a focus on clinical relevance Covers each disease in depth, including etiology, epidemiology, clinics, gross pathology, histopathology, diagnostics, diagnostic criteria, prophylaxis, control, and treatment Written by the world-leading experts in the field of clostridial diseases in animals Offers photographs and summary tables to support the concepts discussed in the text and aid in recognition
Erotic Politics
Identifying the stage as a primary site for erotic display, these essays take eroticism in Renaissance culture as a paradigm for issues of sexuality and identity in early modern culture. Contributors examine how the Renaissance stage functioned as a decoder for erotic experience, both reinforcing and subverting expected sexual behaviour. They argue that the dynamics of theatrical eroticism served to deconstruct gender definitions, leaving conventional categories of sexuality blurred, confused - or absent. In seeking to reposition the conventions and subversions of gender and desire in terms of one another, these essays open up an attractive and distinctive perspective in cultural debate.
