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Advances in Allogeneic Hematopoietic Stem Cell Transplantation
The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes...
The EBMT Handbook
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EBMT HANDBOOK
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Bone Marrow and Stem Cell Transplantation
This volume is a compendium of cutting-edge molecular methods for the successful transplantation of hematopoietic stem cells. The contributors are world-renown leaders in the field. They describe promising tools for stem cell transplant research models, such as in vivo bioluminescence imaging. They discuss HLA typing, PCR-SSP typing, and HLA antigens. This volume is an invaluable source for biochemists, molecular biologists, and clinicians.
Neoplatonism and Jewish Thought
This book deals primarily with the problem of the one and the many. The problems of creation, of evil, of revelation, and of ethics are all treated as special cases of the general problem of relating the finite to the infinite, the many to the one. The authors focus on the unifying theme of mediation, the means by which the Absolute relates to the here and now. The principal figures studied include Philo, Plotinus, Iamblichus, Isaac Israeli, Avicenna, Ibn Gabirol, Al-Ghazâlî, Abraham Ibn Daud, Maimonides, Averroes, Albertus Magnus, Aquinas, Gersonides, Nahmanides, Ibn Falaquera, Narboni, Albalag, Leone Ebreo (Judah Abarbanel), and Spinoza, as well as such Kabbalistic thinkers as Bahir, Cor...
Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases
This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune d...
Chronic Graft Versus Host Disease
Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.
Vaccine Development and the Understanding of Immunity
For centuries, smallpox devastated humanity, killing millions and leaving many scarred. In 1980, the World Health Organization declared smallpox eradicated after a global campaign lasting over 20 years, marking the first elimination of a highly dangerous infectious disease. The development of the smallpox vaccine, from early variolation to modern immunology, has served as a model for inducing long-lasting immunity, secondary immunity, cross-protection, and interactions with the body's microbiota to enhance immune responses. These insights continue to guide vaccine development and immunological research, aiding in the fight against infectious diseases and improving global public health. This book explores the discoveries about the immune system influenced by vaccine development, highlighting the smallpox vaccine's enduring legacy and its testament to the power of immunology and vaccination in disease prevention.
Horace
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