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CNS Cancer
  • Language: en
  • Pages: 1284

CNS Cancer

  • Type: Book
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  • Published: 2009-07-30
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  • Publisher: Humana Press

Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being...

CNS Cancer
  • Language: en
  • Pages: 1294

CNS Cancer

Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being...

Inflammatory Cells and Mediators in CNS Disease
  • Language: en
  • Pages: 541

Inflammatory Cells and Mediators in CNS Disease

  • Type: Book
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  • Published: 2003-09-02
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  • Publisher: CRC Press

This book looks at the causes and long-term effects of inflammation in the CNS as a result of various conditions, and the therapeutic opportunities presented in each case. Each chapter is written by an acknowledged leader in the field

Cytokines and the CNS
  • Language: en
  • Pages: 396

Cytokines and the CNS

  • Type: Book
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  • Published: 2005-10-31
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  • Publisher: CRC Press

Provides Insight into How Cytokine Action Impacts the Physiology and Pathology of the CNS. As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelerating interest in cytokines and cytokine/chemokine signaling over the past several years has encouraged an explosion of literature on cytokines. The similarity between factors involved in inflammation or immunity, and those implicated in neural development, physiology, and repair has become so apparent that familiarity with cytokines must now be considered an essent...

Genomic and Molecular Neuro-oncology
  • Language: en
  • Pages: 384

Genomic and Molecular Neuro-oncology

This book describes and illustrates the latest genomic and molecular techniques that are rapidly transforming the practice of clinical neuro-oncology and the direction of scientific investigation in modern brain tumor research. Each of the chapters provides a review of a specific subfield of contemporary molecular neuro-oncology, including recently implemented diagnostic and research applications. Among the important technical areas covered are the analysis of genomic instability, approaches to tumor invasion and angiogenesis, animal models, gene expression profiling, tissue microarray technology, mRNA splicing, functional genomics and genomics informatics. This book focuses on the latest genomics, molecular, and informatic approaches to neuro-oncology.

Brain Tumor
  • Language: en
  • Pages: 440

Brain Tumor

The title of this monograph, Brain Tumor Research and Therapy, is the name of the Conference itself, which had its inaugural meeting in the United States in 1975 andhas since progressed to the international scale. In Japan, the first conference ofits kind was organized by Dr. Takao Hoshino and me and was held at Nikko in 1980, hence its name, the Nikko Conference on Brain Tumor Research and Therapy. Though it started as a small, closed meeting, the conference has grown considerably, and in 1992 it was reorganized as the Japanese Conference on Brain Tumor Research and Therapy and was opened to all neurosurgeons and neuropathologists interested in the study of brain tumor problems and who are participating in this field. The main purpose of the Conference on Brain Tumor Research and Therapy is the candid and informed discussion of the most up-to-date developments in basic re search and clinical treatment of brain tumors. The 3rd Japanese Conference on Brain Tumor Research and Therapy was held at Nasu (Tochigi Prefecture), Japan, in No vember 1994. It was a great honor to welcome many distinguished guests from over seas who kindly attended each session and made valuable contributions.

Intracranial Germ Cell Tumors
  • Language: en
  • Pages: 462

Intracranial Germ Cell Tumors

Intracranial germ cell tumors are a group of uncommon neoplasms of the central nervous system. The clinical features and natural history of these lesions are quite unique and variable. While intracranial germ cell tumors have been a fascination to neurooncologists for decades, the relatively small number of patients seen in any single institution has hampered the important clinical investigation that is so needed. This text is complete with detailed information concerning the epidemiology, pathology, oncological biology, clinical findings, radiology, and treatment options including surgical strategy, radiotherapy, and chemotherapy for this heterogeneous group of neoplasms. The ongoing clinic...

Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 2
  • Language: en
  • Pages: 754

Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 2

This book aims to gather the current knowledge regarding different aspects of brain and spinal cord tumors in order to more efficiently help the patients. Brain tumors comprise about 5–9% of all human neoplasms; and the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. The more we know about the nature and characteristic of brain and spinal cord tumors, the more precise decision could be made for each patient, in order to reach the best outcome. While surgical resection, chemotherapy, and radiotherapy have been considered as the standards of care for benign and/or malignant CNS tumors since a long time ago, new therapeutic approaches...

Nanoarchitectonics for Brain Drug Delivery
  • Language: en
  • Pages: 381

Nanoarchitectonics for Brain Drug Delivery

  • Type: Book
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  • Published: 2024-02-22
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  • Publisher: CRC Press

This book discusses basics of brain diseases and the role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and the need for novel drug-delivery approaches. It highlights the current route for the intranasal advanced drug-delivery systems for brain diseases. It also discusses innovative categories of drug-delivery systems, including mesoporous silica nanoparticles, polymeric nanocarriers, and lipid-based nanocarriers through multi-responsive DDSs and their implications in brain disorders. Features: Includes an overview of brain diseases and highlights the need for novel drug-delivery approaches Focuses on theoreti...

Adhesion G Protein-coupled Receptors
  • Language: en
  • Pages: 409

Adhesion G Protein-coupled Receptors

  • Type: Book
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  • Published: 2016-11-09
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  • Publisher: Springer

Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.