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Diagnosis, Epidemiology and Treatment of Salivary Gland Carcinomas
Salivary gland carcinomas (SGCs) are a heterogeneous group of rare head and neck cancers made of more than 20 pathologic types. Although the treatments of the early or loco-regionally advanced disease are similar across the different entities, these malignancies have variable biological characteristics and clinical behaviors. These specificities, especially the pathologic type and, when available, the molecular profile, are taken into account while choosing the treatment for the recurrent/metastatic phase. In this context, only few druggable molecular targets have been tested so far and not all are available in clinical practice. However, due to the rarity of SGCs, clinical trials are challenging to conduct, and most of the available evidence comes from retrospective studies.
When the Crisis Becomes an Opportunity
This edited volume analyzes how the COVID-19 crisis could be transformed into opportunities for those organizations that correctly interpret the change, adapt their strategies accordingly, and increase their chances of success in a post-pandemic scenario. Through this lens, the female role and contribution to recovery are analyzed and discussed in the economic, financial and social context. Even if many aspects set the COVID-19 crisis apart from the latest global financial crises – such as the unusual shutdown of businesses in specific sectors, social distancing regulations, and general uncertainty sparked by the pandemic – the challenges facing all organizations in the current recovery phase can present an opportunity for extraordinary growth and development in Europe. The focus of the contributions gathered here is not on “counting” the damages and losses but rather on monitoring the recovery and on emerging instruments to support national and global economic recovery, while paying special attention to women’s role in it.
Anterior Skull Base Tumors
In recent years, interest in the management of anterior skull base tumors has been fostered by the introduction and subsequent rapid expansion of indications of transnasal endoscopic techniques. In parallel, extraordinary progress has been made in all the other disciplines which are involved in the complex process of managing anterior skull base tumors, leading to substantial improvements in diagnosis and treatment. The anterior skull base can be involved in a large variety of tumors of a varying nature and histology, which in the majority of cases originate from adjacent anatomic sites. In fact, primary lesions of the anterior skull base mainly include osteoma and other tumors originating f...
Advances in Radiotherapy for Head and Neck Cancer
Modern Radiotherapy (RT) plays a key role in the management of Head and Neck Cancer (HNC). More precise delivery techniques, advanced image-guidance, and adaptive treatments characterize modern RT, enabling safer treatments with enhanced therapeutic window. Although patients identify the cure as their most important treatment outcome, complications related to treatment are a recognized problem as follow-up increases among those cured within this oncologic setting. This is particularly relevant for HPV-related oropharyngeal cancer (OPSCC), as these patients are younger, healthier, and more reactive to treatment. Thus, given the longer life expectancy, the jeopardizing impact of side effects on quality of life (QoL) and psychosocial functioning represent a forefront topic for HNC Researchers. De-escalation protocols have been developed recently, and, although not definitive, evidence is growing. This pertains particularly, but not exclusively, to HPV-related OPSCC.
Salivary Gland Cancer
This clinically oriented book provides a comprehensive update on the biology, diagnosis, and treatment of salivary gland cancer. Detailed information is presented on molecular characterization and radiological staging, and a series of treatment-related chapters describe the different surgical approaches to major and minor salivary gland cancer, including reconstructive surgery techniques, and the roles of radiotherapy and heavy ion therapy. Rehabilitation, follow-up, and the management of metastatic disease are also fully discussed. The aim is to equip the reader with the knowledge required to deliver appropriate tailored treatment in each patient, based on tumor characteristics and other pertinent factors. An additional feature is the inclusion of information on advocacy groups and their perspectives. All of the chapters are written by leading specialists in the field. In presenting the most recent advances and innovations in diagnosis and therapy and relating them to individualized treatment, this book will appeal to a wide audience including otorhinolaryngologists, head and neck surgeons, maxillofacial surgeons, radiation oncologists, and other clinicians.
