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In most peroxisomal disorders the nervous system is severely affected which explains the clinical and community burden they represent. This is the first book to focus not only on the mutations causing these inherited illnesses, but also on mechanisms that regulate, suppress or enhance expression of genes and their products (enzymes). Indeed since the success and completion of the Human Genome Project all genes (coding DNA sequences) are known. However, of many, their function, and the role of the gene product has not been determined. An example is X-linked adrenoleukodystrophy, the most frequent peroxisomal disorder. Children are born healthy, but in more than 1 out of 3, demyelination of the brain starts unpredictably and they die in a vegetative state. The gene mutated in most families has been known for 10 years; but the true role of the encoded protein, ALDp, is still speculative; and within the same family, very severe and asymptomatic clinical histories co-exist, unexplained by the mutation.
Memoirs of a Jew, born Meta Königsthal in 1914 in Karlshafen (Hessen), who managed, together with her husband, to emigrate to Palestine in 1934, while 99 members of her family perished in the Holocaust. Pp. 11-34 relate events until their emigration. With the rise of the Nazi regime, her then fiance, Kurt Frank, was expelled from the University of Giessen, where he had almost completed his medical studies. He immediately left Germany, and began an apprenticeship on a farm in Holland. They applied for a certificate for Palestine and were married on 4 September 1934 in Karlshafen. On 28 October 1934 they left Germany.
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The exhibition "Assyria to Iberia at the Dawn of the Classical Age" (The Metropolitan Museum of Art, New York, 2014) offered a comprehensive overview of art and cultural exchange in an era of vast imperial and mercantile expansion. The twenty-seven essays in this volume are based on the symposium and lectures that took place in conjunction with the exhibition. Written by an international group of scholars from a wide variety of disciplines, they include reports of new archaeological discoveries, illuminating interpretations of material culture, and innovative investigations of literary, historical, and political aspects of the interactions that shaped art and culture in the in the early first millennium B.C. Taken together, these essays explore the cultural encounters of diverse populations interacting through trade, travel, and migration, as well as war and displacement, in the ancient world. Assyria to Iberia: Art and Culture in the Iron Age contributes significantly to our understanding of the epoch-making exchanges that spanned the Near East and the Mediterranean and exerted immense influence in the centuries that followed.