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Advances in Cancer Research
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including chromosome instability in cancer; telomerase inhibitors as an option for chemotherapy; avian retrovirus pathogenicity; Epstein-Barr virus and undifferentiated nasopharyngeal carcinoma; immunotherapy for prostate cancer; and the role of lymphocytes in anti-tumor immunity. Provides invaluable information on the exciting and fast-moving field of cancer research. Presents outstanding and original reviews on a variety of topics, including chromosome instability in cancer; telomerase inhibitors as an option for chemotherapy; avian retrovirus pathogenicity; Epstein-Barr virus and undifferentiated nasopharyngeal carcinoma; immunotherapy for prostate cancer; and the role of lymphocytes in anti-tumor immunity
Immunobiotics: Interactions of Beneficial Microbes with the Immune System
The term “immunobiotics” has been proposed to define microbial strains able to beneficially regulate the mucosal immune system. Research in immunobiotics has significantly evolved as researchers employed cutting-edge technologies to investigate the complex interactions of these beneficial microorganisms with the immune system. During the last decade, our understanding of immunobiotics-host interaction was profoundly transformed by the discovery of microbial molecules and host receptors involved in the modulation of gut associated immune system, as well as the systemic and distant mucosal immune systems. In recent years, there has been a substantial increase in the number of reports descr...
Microenvironment-Derived Stem Cell Plasticity
Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.
The nature of activatory and tolerogenic dendritic cell-derived signal 2
One of the most interesting issues in immunology is how the innate and adaptive branches of the immune system cooperate in vertebrate organisms to respond and destroy invading microorganisms without destroying self-tissues. More than 20 years ago, Charles Janeway proposed the innate immune recognition theory [1]. He hypothesized the existence of innate receptors (Pattern recognition receptors, PRRs) that, by recognizing molecular structures associated to pathogens (PAMPs) and being expressed by antigen presenting cells (APCs) and epithelial cells, could alert the immune system to the presence of a pathogen, making it possible to mount an immediate inflammatory response. Moreover, by transduc...
Molecular Immunology
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Scientific Report
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Inner Paths to Outer Space
An investigation into experiences of other realms of existence and contact with otherworldly beings • Examines how contact with alien life-forms can be obtained through the “inner space” dimensions of our minds • Presents evidence that other worlds experienced through consciousness-altering technologies are often as real as those perceived with our five senses • Correlates science fiction’s imaginal realms with psychedelic research For thousands of years, voyagers of inner space--spiritual seekers, shamans, and psychoactive drug users--have returned from their inner imaginal travels reporting encounters with alien intelligences. Inner Paths to Outer Space presents an innovative e...
Drugs During Pregnancy and Lactation
The care of pregnant women presents one of the paradoxes of modern medicine. Women usually require little medical intervention during an (uneventful) pregnancy. Conversely, those at high risk of damage to their own health or that of their unborn require the help of appropriate medicinal technology, including drugs. Accordingly, there are two classes of pregnant women, the larger group requires support but not much intervention, while the other needs the full range of diagnostic and therapeutic measures applied in any other branch of medicine. This book presents the current state of knowledge about drugs in pregnancy. In each chapter information is presented separately for two different aspects of the problem seeking a drug appropriate for prescription during pregnancy, and assessing the risk of a drug when exposure has already taken place. Practising clinicians who prescribe medicinal products to women who are, or who may become, pregnant, will find this volume an invaluable reference.
Mass Spectrometry of Peptides
The purpose of this book is to collect into one volume the research done on the mass spectrometry of peptides. It balances a range of topics including theory, instrumentation, analytical techniques, and biological applications. The scope of the work contains three major sections: ionization methods, instrumental developments, and analysis of peptides. It describes 252Cf plasma desorption and laser-induced multiphoton ionization methodology. This exciting resource covers many new areas, including continuous flow FAB, quantification of human neuropeptides, and peptide mapping. It also discusses Q-FTMS, cross-links, and metal ions.
