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The disorders induced by iodine deficiency affect at least one billion people. Because ofits effects on brain development, iodinedeficiency is the single most preventable cause of mental retardation in the world. Therefore, the United Nations and the Heads of State of almost all the world's countries represented at the Summit for Children in 1990 adopted resolutions to eradicate the disorders induced by iodine deficiency (IDD) by the year 2000. For geological and socio-economic reasons, most of the populations affected by iodine deficiency disorders live in isolated and usually mountainous areas, in pre industrialized parts ofthe world. The problem of iodine deficiency in Europe has been gre...
Systematic screening for congenital hypothyroidism in the newborn was introduced some 15 years ago. The main objective was the prevention of mental retardation due to thyroid hormone deficiency during the early months of life. During the past decade screening programs have become routine throughout most of the industrialized world and many questions relating to implementation, organization and quality control of such programs have been largely resolved. Preliminary IQ and neurological data have indicated that screening and early treatment do, in fact, prevent mental retardation. However, a number of scientific questions related to congenital hypothyroidism remain unanswered and extensive res...
In many parts of the world, deficiencies in vitamins, minerals and trace elements during the early months of life have dramatic consequences on the health and development of infants and young children. The nutritional status of the mother greatly influences breast-milk micronutrient levels and hence the nutritional status of the infant. This publication, written by leading investigators and clinicians, offers an up-to-date review of micronutrient requirements and the assessment of micronutrient status of mothers and young infants, followed by the epidemiology and health consequences of micronutrient deficiencies. It also includes different prophylactic and therapeutic approaches, such as the most recent research on both single and multiple micronutrient interventions during pregnancy, lactation and early infancy. This publication will be of great assistance to pediatricians, clinical investigators, health workers and nutritionists engaged in the prevention and treatment of micronutrient deficiencies.
Completely updated for its Ninth Edition, this classic text provides comprehensive coverage of every aspect of thyroid anatomy, development, biochemistry, physiology, pathophysiology, and treatment of all thyroid disorders. This edition has a more international group of contributors and new chapters on mortality in thyroid disease, oncogenes, radioiodine treatments for carcinoma, trophoblastic tumors, and subacute and acute infectious thyroiditis. Chapters address clinical controversies regarding subclinical hypothyroidism and hyperthyroidism. The section on laboratory assessment of thyroid function has been reorganized for easier look-up of function tests.
A balanced view of the causes and the prevention of the iodine defi-ciency disorders is presented in this comprehensive text. The mechanisms of goitrogenesis are explained, along with preven-tive and control measures. Descriptions of environmental com-pounds and other ecological as well as host factors involved in this process are highlighted. Public health and economic impact of the problems and treatment of individual cases are discussed. Overview sections include: Environmental goitrogenesis Sulfurated organics Flavonoids Polyhydroxyphenols and phenol derivatives Phthalate esters and phthalic acid derivatives Polyhalogenated and polycyclic aromatic hydrocarbons Hydroxypyridines Inorganics Epidemiological aspects of environmental goitrogenesis Goiter endemias attributed to goitrogens in foodstuffs Goiter endemias attributed to chemical and bacterial pollution of water supplies
Public Health
Perinatal problems in thyroid gland physiology are common but complicated and present a diagnostic dilemma for the primary clinician. In December 1990, an international group of basic and clinical investigators gathered in Longboat Key, Florida to address these issues. The participants included internists, obstetricians, pedia tricians, neurologists, pathologists and basic scientists in cellular metabolism, endocrine physiology, and molecular biology. The presentations contained within this book bring together their most current and vital research related to the field of perinatal thyroidology. This book is based on the dynamic and fruitful exchange of the participants at the symposium. We a...