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Myeloproliferative Neoplasms
  • Language: en
  • Pages: 235

Myeloproliferative Neoplasms

This book focuses on three of the main categories of myeloproliferative neoplasm: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Relevant laboratory and clinical advances are comprehensively covered, and great emphasis is placed on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic approaches, the value and limitations of mutation screening for diagnostic and prognostic purposes, risk stratification in terms of both survival and other disease complications such as leukemic transformation and thrombosis, and modern therapeutic strategies, including conventional drugs, allogeneic stem cell transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.

Cancer Cytogenetics
  • Language: en
  • Pages: 799

Cancer Cytogenetics

Cancer Cytogenetics, 3rd Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area and incorporates a vast amount of new data from the latest basic and clinical investigations. Edited by two leading experts, and now involving a new panel of international experts, the book offers an authoritative description of neoplastic processes at the chromosomal level of genomic organization. Researchers in cytogenetics, medical and molecular genetics, cellular and molecular biology, cancer research, clinical oncology, and hematology will find this reference both thorough and authoritative.

The Foundations of Complex Evolving Economies
  • Language: en
  • Pages: 753

The Foundations of Complex Evolving Economies

The Foundations of Complex Evolving Economies seeks to offer an integrated analysis of the anatomy and physiology of the capitalist engine of generation and exploitation of technological organizational and institutional innovations - from the drivers of knowledge accumulation, to the modes in which such knowledge is incorporated into business firms, all the way to the processes of innovation-driven “Schumpeterian competition” and macroeconomic growth. In that, it advances the interpretation of such patterns, in terms of economies seen as complex evolving systems. The basic objects of analysis are the history of the emergence and development of modern capitalist economies and their curren...

Regional Resilience to Climate and Environmental Shocks
  • Language: en
  • Pages: 118

Regional Resilience to Climate and Environmental Shocks

The book illustrates the use of spatial econometric models to analyze the economic resilience of regions to climate-related shocks. Although climate change is a global externality, climate anomalies can trigger locally disruptive shocks, whose adverse effects on economic growth are transmitted through neighbouring relationships (based on geography, trade, or technological bonds). After laying out the theoretical case for spatial analysis in the study of economic resilience, the book introduces spatial econometric models, their estimation and testing procedures, as well as applications of spatial econometrics in various domains. It then reviews the current literature on the role of space in the propagation of climate shocks, and discusses how adaptation and mitigation policies can leverage spatial dependencies, with a special focus on renewable energy technologies and agricultural productivity. It appeals to scholars of regional and spatial sciences and econometrics as well as those interested in the spatial effects of climate and environmental shocks.

Molecular Aspects of Hematologic Malignancies
  • Language: en
  • Pages: 468

Molecular Aspects of Hematologic Malignancies

This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors’ own laboratories.

Computer Simulation Validation
  • Language: en
  • Pages: 1056

Computer Simulation Validation

  • Type: Book
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  • Published: 2019-04-09
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  • Publisher: Springer

This unique volume introduces and discusses the methods of validating computer simulations in scientific research. The core concepts, strategies, and techniques of validation are explained by an international team of pre-eminent authorities, drawing on expertise from various fields ranging from engineering and the physical sciences to the social sciences and history. The work also offers new and original philosophical perspectives on the validation of simulations. Topics and features: introduces the fundamental concepts and principles related to the validation of computer simulations, and examines philosophical frameworks for thinking about validation; provides an overview of the various str...

Catalogue of the London Library ...
  • Language: en
  • Pages: 522

Catalogue of the London Library ...

  • Type: Book
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  • Published: 1888
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  • Publisher: Unknown

None

The Strad
  • Language: en
  • Pages: 472

The Strad

  • Type: Book
  • -
  • Published: 1896
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  • Publisher: Unknown

None

The Routledge Handbook of Sociolinguistics Around the World
  • Language: en
  • Pages: 992

The Routledge Handbook of Sociolinguistics Around the World

Drawing on examples from a wide range of languages and social settings, The Routledge Handbook of Sociolinguistics Around the World was originally the first single-volume collection surveying the current research trends in international sociolinguistics. This new edition has been comprehensively updated and significantly expanded, and now includes more than 50 chapters written by leading authorities and a brand-new substantial introduction by John Edwards. Coverage has been expanded regionally and there is a critical focus on Indigenous languages. This handbook remains a key tool to help widen the perspective on sociolinguistics to readers interested in the field. Divided into sections cover...

Computational Science – ICCS 2020
  • Language: en
  • Pages: 726

Computational Science – ICCS 2020

The seven-volume set LNCS 12137, 12138, 12139, 12140, 12141, 12142, and 12143 constitutes the proceedings of the 20th International Conference on Computational Science, ICCS 2020, held in Amsterdam, The Netherlands, in June 2020.* The total of 101 papers and 248 workshop papers presented in this book set were carefully reviewed and selected from 719 submissions (230 submissions to the main track and 489 submissions to the workshops). The papers were organized in topical sections named: Part I: ICCS Main Track Part II: ICCS Main Track Part III: Advances in High-Performance Computational Earth Sciences: Applications and Frameworks; Agent-Based Simulations, Adaptive Algorithms and Solvers; Appl...