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Kazakhstan Central Concert Hall. Manfredi Nicoletti con Luca F. Nicoletti
Il progetto rappresenta ciò di cui il luogo manca, un suo possibile completamento. Andando ad Astana e sorvolando la steppa russa, i suoi laghi di sale, la sua terra piatta e deserta, le carcasse pietrificate di alberi contorti, abbiamo sentito la mancanza di un fiore che si apra nel cuore di questa città, per colmare tale assenza. The project represents what the place lacks, its possible completion. Going to Astana and flying over the Russian steppe, its salt lakes, its flat and deserted land, its petrified carcasses of crabbed trees, we noticed the lack of a flower that opens in the heart of this city, and decided to fill this absence. Manfredi Nicoletti, Master in Architecture M.I.T., U...
Excitatory Amino Acids
This past decade has led to many significant advances in the understanding of the function of excitatory amino acids in synaptic transmission. The cloning of the ionotropic and metabotropic glutamate receptor families of receptor proteins has produced new strategies for the pharmacological modulation of glutamate transmission. The engineering of transgenic animals with modified expression of receptor proteins has created new insights into the function, dysfunction and possible pathology causally related to glutamate receptors. Advances in the pharmacology of glutamate receptors has led to clinical research addressing multiple therapeutic applications of drugs that act on excitatory amino acid systems. A number of NMDA receptor anatagonists have now been studied in humans. AMPA/kainate and metabotropic receptor active compounds have left the preclinical realms of research and have moved towards or are in the clinic.
The Goshawk
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Excitotoxicity in Neurological Diseases
It can be reasonably anticipated that, over the next generations, the proportion of elderly people will remarkably increase and, with this, the number ofpersons suffering from acute (e.g. cerebral ischemia) or chronic neurodegenerative disorders. To date, approved drugs only alleviate the symptoms ofthese diseases (for instance, acetylcholinesterase inhibitors in Alzheimer disease and L-dopa and dopamine-agonists in Parkinson disease), while none seems to stop the progression of the degenerative processes underlying them. The development of effective preventive or protective therapies has been impeded by the limitations of our knowledge of the causes and the mechanisms by which neurons die i...
Transcription Factors
Transcription Factors Normal and Malignant Development of Blood Cells Katya Ravid and Jonathan Licht The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification...
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
Imported Virus Infections
This book deals both with the epidemiologic background and the specific characteristics of vector-borne and emerging viral infections which may be spread all over the world due to today’s rapid transport of infected individuals or animal vectors. Detailed description of the situation with e.g. Dengue, Japanese encephalitis, Lassa, hepatitis, HIV and filoviruses helps to plan diagnostic approaches and to develop scenarios for the handling of patients suspected of carrying high hazard viruses.
Arthroscopy and Endoscopy of the Elbow, Wrist and Hand
This book explores the numerous recent advances in arthroscopic and endoscopic surgery of the smaller joints of the upper extremity – elbow, wrist, and hand. Providing readers with all necessary information, i.e. relevant surgical anatomy and a clear description of technical steps, it uniquely and comprehensively presents arthroscopic and endoscopic techniques of small joints in one publication. The procedures are subdivided according to the pathology (instability, fractures, etc.) or grouped by the region within the anatomical area and include the relevant anatomy, extensive cadaveric dissections, devices and instrumentation, surgical procedures, pearls and pitfalls. High-quality colour illustrations further simplify and complement the description of surgical techniques. Written by pioneers of these techniques, the book is designed to be an up-to-date reference resource for both new and advanced orthopaedic surgeons wanting to become familiar with these techniques.
