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Molecular Machines Involved in Peroxisome Biogenesis and Maintenance
In eukaryotes, lipid metabolism requires the function of peroxisomes. These multitasking organelles are also part of species-specific pathways such as the glyoxylate cycle in yeast and plants or the synthesis of ether lipid in mammals. Proteins required for the biogenesis of peroxisomes typically assemble in large molecular complexes, which participate in membrane formation, protein transport, peroxisome duplication and - inheritance during cell division. Peroxisomal function is essential for life. Mutations in PEX genes, encoding for biogenesis factors, are often associated with lethal disorders. The association of peroxisomes with other organelles suggests an extensive participation in organellar crosstalk. This book represents a state-of-the-art review in the field of peroxisome research encompassing the cell and molecular biology of peroxisome biogenesis and its diseases, the protein complexes involved in this process and the modern technologies applied to study them. The book is intended for graduate students, researchers and lecturers in biochemistry, molecular and cell biology with a biomedical background.
Proteomics of Peroxisomes
This new edited volume in the Springer Subcellular Biochemistry Series presents a comprehensive, state-of-the-art overview of the proteomics of peroxisomes derived from mammalian, Drosophila, fungal, and plant origin, and contains contributions from leading experts in the field. The development of sensitive proteomics and mass spectrometry technologies, combined with bioinformatics approaches now allow the identification of low-abundance and transient peroxisomal proteins and permits to identify the complete proteome of peroxisomes, with the consequent increase of our knowledge of the metabolic and regulatory networks of these important cellular organelles. The book lines-up with these devel...
Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation
Eukaryotic cells contain distinct membrane-bound organelles, which compartmentalise cellular proteins to fulfil a variety of vital functions. Many organelles have long been regarded as isolated and static entities (e.g., peroxisomes, mitochondria, lipid droplets), but it is now evident that they display dynamic changes, interact with each other, share certain proteins and show metabolic cooperation and cross-talk. Despite great advances in the identification and characterisation of essential components and molecular mechanisms associated with the biogenesis and function of organelles, information on how organelles interact and are incorporated into metabolic pathways and signaling networks i...
Fabian
First published in German in 1931, the first English edition of this book was published in 1932 by Jonathan Cape in an expurgated edition. Set in the crumbling Berlin of the 1920s, it is a tale of despair. This edition is unexpurgated. The author also wrote Emil and the Detectives.
Das Ende der Erschöpfung
Wir sind am Ende - also fangen wir anders an: Denken wir eine Welt ohne Wachstum! Die Klimakrise verändert die Welt unwiederbringlich. Unser Wirtschaftssystem gerät an seine Grenzen und die Ungleichheiten verstärken sich weiter. Unser Alltag, unser Weltbild und unser Vorstellungsvermögen werden von multiplen Krisen erschüttert. Woher also die Kraft nehmen, sich jetzt auch noch mit Wirtschaftstheorie zu beschäftigen? Ganz einfach: Unsere Existenz ist davon abhängig. Katharina Mau stellt Lösungsansätze und Ideen vor, die wirtschaftliche, ökologische und soziale Ressourcen berücksichtigen und sich nicht nur an höher, schneller, weiter orientieren. Denn sich vorzustellen, wie eine ge...
Database and Expert Systems Applications - DEXA 2022 Workshops
This volume constitutes the refereed proceedings of the workshops held at the 33rd International Conference on Database and Expert Systems Applications, DEXA 2022, held in Vienna, Austria, in August 2022: The 6th International Workshop on Cyber-Security and Functional Safety in Cyber-Physical Systems (IWCFS 2022); 4th International Workshop on Machine Learning and Knowledge Graphs (MLKgraphs 2022); 2nd International Workshop on Time Ordered Data (ProTime2022); 2nd International Workshop on AI System Engineering: Math, Modelling and Software (AISys2022); 1st International Workshop on Distributed Ledgers and Related Technologies (DLRT2022); 1st International Workshop on Applied Research, Technology Transfer and Knowledge Exchange in Software and Data Science (ARTE2022). The 40 papers were thoroughly reviewed and selected from 62 submissions, and discuss a range of topics including: knowledge discovery, biological data, cyber security, cyber-physical system, machine learning, knowledge graphs, information retriever, data base, and artificial intelligence.
