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Lipid Metabolism and human diseases
Lipids such as cholesterol, phospholipids, triglycerides, and free fatty acids, play various essential physiological roles. Dysregulation of lipid metabolism causes dyslipidemia, which is a critical factor in the development of various human diseases, such as cardiovascular disease, diabetes, non-alcoholic fatty liver disease, Alzheimer's disease, and Niemann-Pick disease. Therefore, lipid homeostasis in humans is strictly regulated by a well-balanced mechanism of intestinal uptake, endogenous synthesis and metabolism, and transport in lipoprotein particles and excretion. The human body evolves multiple mechanisms to maintain lipid homeostasis, such as low-density lipoprotein receptor mediates clearance of circulating low-density lipoprotein cholesterol; phospholipid transfer protein mediates the transfer of phospholipids from apoB-containing triglyceride-rich lipoprotein to high-density lipoprotein, etc.
Myokines, Adipokines, Cytokines in Muscle Pathophysiology
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Aufgetau(ch)t
Nach dem Tod des Vaters verfällt die nach Deutschland immigrierte Familie Selcan in tiefe Depressionen. Die Mutter hat weder das Geld noch die Kraft für ihre Kinder zu sorgen während sich die Krankheit ihres 15-Jährigen autistischen Sohns Fabio zunehmend verschlechtert. Einzig Esme, die Tochter versucht ihre Familie und sich in dem neuen Land zu integrieren. Als sie das Jugendamt einschaltet, welches entscheidet dass Fabio trotz seiner Krankheit eine Schule besuchen muss, bemerkt dieser dort seinen besonderen Bezug zu der deutschen Sprache. Während sich Esme und ihre traumatisierte Mutter stets um die Zukunft Fabios streiten entwickelt er eine eigene Technik wieder stärker an der Realität teilzunehmen: Er sprayt Graffitis, schreibt Gedichte und erzählt Geschichten. Denn in den Momenten, in denen er selbst schreibt verlässt er seine eigene Welt und nimmt die Umwelt ausnahmsweise wahr. So entwickelt sich ein innerlicher Kampf zwischen seiner Krankheit und dem Wunsch mit seinem Talent für Sprache ein Leben wie die anderen leben zu können...
Consumidos pelo reino
A motivação deste livro veio pelos dez anos da publicação da obra A profecia do avivamento, numa proposta de revisão de vida diante de uma grandiosa inspiração que o Senhor nos deu. Recebemos dele uma visão e também uma missão e, consequentemente, valores que foram vividos por nós, dos quais não podemos, em hipótese alguma, abrir mão. Tudo começou de uma forma muito simples e despretensiosa, quando éramos despertados de madrugada para orar pela transformação do Brasil. Num primeiro momento, rezávamos cada um na sua própria casa, depois fomos sendo ajuntados para rezar e colher as estratégias do Espírito Santo. Foram madrugadas extraordinárias na presença do Senhor. "Não dá mais para voltar, o barco está em alto mar."
