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With advances in medicine and medical innovation, the face of neurosurgery has changed dramatically. A new era of surgeons values the need to undertake research in everyday practice and actively participate in the clinic and laboratory in order to improve patient prognosis. Highlighting the principles of basic neuroscience and its application to neurosurgical disease, this book breaks down neurological conditions into current academic themes and advances. The book is split into two sections, with the first covering basic and computational neuroscience including neuroanatomy, synaptic transmission and the growing use of artificial intelligence. The second section concentrates on specific conditions, such as gliomas, spinal tumors, and peripheral nerve injury. Outlining the clinical and pathophysiological principles of neurological conditions, this valuable book describes key animal models, helping clinicians design and conduct appropriate research projects to further knowledge and improve prognosis.
Cardiovascular diseases (CVDs) are the leading cause of death globally. Poor dietary habits appear to be the major modifiable risk factor for morbidity and mortality from CVDs. Therefore, improving dietary habits and adopting food- and nutrient-based dietary guidelines as part of a global public health strategy is of critical importance to preventing and managing end-stage disease, thereby reducing the direct and indirect costs associated with CVDs. Data from the Global Burden of Disease Study 2017 suggest that over 80% of disability-adjusted life years and deaths resulting from poor diet are a result of cardiovascular health issues. In many instances, the underlying mechanism linking intake of food, nutrients or whole diets to cardiovascular function has not been fully elucidated.
Written by experts from London’s renowned Royal Free Hospital, Textbook of Plastic and Reconstructive Surgery offers a comprehensive overview of the vast topic of reconstructive plastic surgery and its various subspecialties for introductory plastic surgery and surgical science courses. The book comprises five sections covering the fundamental principles of plastic surgery, cancer, burns and trauma, paediatric plastic surgery and aesthetic surgery, and covers the breadth of knowledge that students need to further their career in this exciting field. Additional coverage of areas in which reconstructive surgery techniques are called upon includes abdominal wall reconstruction, ear reconstruc...
Metabolic disorders, including obesity, type 2 diabetes, insulin resistance, and cardiovascular disease are alarmingly rising around the globe and causing major health problems leading to significant morbidity and mortality. Many essential nutrients and minerals play a vital role in maintaining metabolic homeostasis. Phosphate, calcium, magnesium, zinc, selenium, iron, and vitamins are required for controlling the homeostatic balance of cells and tissue functions. Earlier works by Hartman et al. have shown that salivary phosphate levels can predict the genesis of obesity in children. Despite progress in our understanding of pathomechanism of metabolic diseases, there are knowledge gaps of how dysregulations of various minerals and nutrients are triggering and propagating metabolic disorders.
This issue of Neurosurgery Clinics, edited by Dr. Michael G. Fehlings and Dr. Junichi Mizuno, focuses on Cervical Myelopathy. Topics include, but are not limited to, Epidemiology and overview of the clinical spectrum of degenerative cervical myelopathy; Pathobiology of degenerative cervical myelopathy; Natural history of degenerative cervical myelopathy; Imaging evaluation of degenerative cervical myelopathy: current state of the art and future directions; Pathophysiology of CPPD and OYL(OLF); Radiological evaluation of OPLL with dural ossification; Relationship of OALL, OPLL and OYL (OLF); Importance of sagittal alignment of the cervical spine in the management of degenerative cervical myel...
Assessing health-related quality of life (HRQOL) of Children has been a popular topic in recent years worldwide. However, there are several issues/gaps in this research area which need to be addressed. For instance, previous studies on HRQOL of Children populations have normally used HRQOL instruments designed for adults. These measurements may not be suitable for children as they are in a series of cognitive developmental stages and have different perspectives towards the relative importance of HRQOL dimensions. In order to tackle this issue and to accurately measure children’s HRQOL, a set of dedicated HRQOL instruments should be first developed and validated. The validated instruments could then be applied to the population measuring their HRQOL. In addition, the HRQOL information collected could be translated into health utility score if it is measured by utility instruments (e.g., EQ-5D-Y) for the population. Moreover, the relevant studies on these issues is still lacking especially in non-western countries.
Obesity is a serious health issue and is a key discussion and research point in several disciplines from the social sciences to the health sciences and even in physical education. This text is a much-needed authoritative reference source covering major issues of, and relating to, obesity.
Tissue Engineering Made Easy provides concise, easy to understand, up-to-date information about the most important topics in tissue engineering. These include background and basic principles, clinical applications for a variety of organs (skin, nerves, eye, heart, lungs and bones), and the future of the field. The descriptions and explanations of each topic are such that those who have not had any exposure to the principles and practice of tissue engineering will be able to understand them, and the volume will serve as a source for self-teaching to get readers to a point where they can effectively engage with active researchers. - Offers readers a truly introductory way to understand the concepts, challenges and the new trends in reconstructive medicine - Features accessible language for students beginning their research careers, private practice physician collaborators, and residents just beginning their research rotation - Addresses the specifics for a variety of organs/systems – nerves, skin, bone, cardiovascular, respiratory, ophthalmic - Provides examples from clinical and everyday situations
This encyclopedia will define the issues that surround cancer and its effects on society.
In many respects, the continent of Africa is in transition. Prominent among them – currently – is the nutrition transition. One consequence of the nutrition transition is the increase in prevalence of nutrition-related non-communicable diseases (NCDs) such as obesity, type 2 diabetes, cardiovascular diseases, and certain cancers. Although NCDs are a global public health problem, the rate of increase in NCDs morbidity and mortality in some African countries is staggering. This surge has been linked to modifiable environmental factors – factors that facilitate the consumption of obesogenic (energy-dense nutrient-poor foods), rather than unrefined cereals, fruits, and vegetables. It has long been recognized that the physical and social environments - in which people live, work, and eat are critical determinants of their health. More recently, there has been a greater focus on the food environment as a key determinant of health. Available evidence shows that unhealthy food environments drive unhealthy diets; and unhealthy diet is one of four main risk factors for NCDs.