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CD4+ FOXP3+ Regulatory T Celles Homeostasis
Regulatory T cells (Treg) represent a crucial CD4 T cells subset involved in maintenance of immune-tolerance. Since their first description important efforts have been undertaken to better understand their biology, their development and their mechanisms of action. However, little is known about factors controlling Treg peripheral homeostasis. The aim of this thesis work was to better define mechanisms involved in governing Treg homeostasis and to investigate the eventual contribution of perturbation of Treg homeostasis in human disease. In the first part of this thesis work we tried to define in the murine system the role played by IL-7 in governing Treg homeostasis. We showed that Treg surf...
NK Cell Subsets in Health and Disease: New Developments
Natural Killer (NK) cells were discovered ca 1975, as the first group of lymphoid cells that were neither T cells nor B cells. Since then, the dissection of the biology of NK cells has been growing exponentially with many seminal discoveries from the identification of MHC class I-specific inhibitory receptors to the discovery of receptor-ligand pairs involved in NK cell activation and to the manipulation of NK cells in cancer. In this research topic, we asked a group of thought leaders in NK cell biology to review recent advances in their origins and biology, and their roles in cancer, infection and inflammation. Together, these 25 articles provide a timely survey of NK cells as critical immunologic components of health and disease. They will hopefully prompt further dialogue and developments in basic and translational immunology.
The Montefeltro Conspiracy
A brutal murder, a nefarious plot, a coded letter. After five hundred years, the most notorious mystery of the Renaissance is finally solved. The Italian Renaissance is remembered as much for intrigue as it is for art, with papal politics and infighting among Italy’s many city-states providing the grist for Machiavelli’s classic work on take-no-prisoners politics, The Prince. The attempted assassination of the Medici brothers in the Duomo in Florence in 1478 is one of the best-known examples of the machinations endemic to the age. While the assailants were the Medici’s rivals, the Pazzi family, questions have always lingered about who really orchestrated the attack, which has come to b...
Tale of Rouen
It is said "those who [do not] remember the past are [doomed] to repeat it." - George Santayana But sometimes necessary secrets trap one in an endless cycle of tragedy. Jillian, a divorced researcher, travels to Urbino, Italy, to get away from life in the United States. While she explores the winding cobblestone streets of the mountaintop town, she encounters a man from the Renaissance. Initially, she thinks he is a costumed tour guide, then she learns he is a ghost with a strange story. Rouen is cursed to wander within the boundaries of Urbino for a thousand years. Jillian is the first person in over a century to notice that he exists. Although it goes against his better judgement, he befri...
