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Single Cell Sequencing and Systems Immunology
The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author’s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lympho...
Handbook of Molecular Microbial Ecology II
The premiere two-volume reference on revelations from studying complex microbial communities in many distinct habitats Metagenomics is an emerging field that has changed the way microbiologists study microorganisms. It involves the genomic analysis of microorganisms by extraction and cloning of DNA from a group of microorganisms, or the direct use of the purified DNA or RNA for sequencing, which allows scientists to bypass the usual protocol of isolating and culturing individual microbial species. This method is now used in laboratories across the globe to study microorganism diversity and for isolating novel medical and industrial compounds. Handbook of Molecular Microbial Ecology is the fi...
Recent Advances in Geomicrobiology of the Ocean Crust
Igneous oceanic crust is one of the largest potential habitats for life on earth, and microbial activity supported by rock-water-microbe reactions in this environment can impact global biogeochemical cycles. However, our understanding of the microbiology of this system, especially the subsurface “deep biosphere” component of it, has traditionally been limited by sample availability and quality. Over the past decade, several major international programs (such as the Center for Dark Energy Biosphere Investigations, the current International Ocean Discovery Program and its predecessor Integrated Ocean Drilling Program, and the Deep Carbon Observatory) have focused on advancing our understan...
Provincial Strategies of Economic Reform in Post-Mao China
Focusing on the role of provincial leadership in the initiation and implementation of economic reform, this text studies economic decentralization in eight Chinese provinces. In each area, resource allocation and acquisition of foreign capital and investment are investigated.
Life at Vents and Seeps
Vents and seeps are the epitome of life in extreme environments, but there is much more to these systems than just black smokers or hydrocarbon seeps. Many other ecosystems are characterized by moving fluids and this book provides an overview of the different habitats, their specific conditions as well as the technical challenges that have to be met when studying them. The book provides the current state of the art and will be a valuable resource for everybody that has an interest in such environments.
Mysteries of the Deep
A groundbreaking chronicle of scientific ocean drilling—a crowning achievement of the twentieth century—and how it shaped our knowledge of Earth's past. Under the radar—or, rather, sonar—of most people and many scientists, for the last six decades ships have plied the world’s oceans, mining the seafloor for its secrets—and quietly resolving confounding geological mysteries. Continental drift and plate tectonics. The origin of the Hawaiʻian Islands. The erstwhile disappearance of the Mediterranean. The mystery of the ice ages. All are part of the story told by deep-sea drilling—and chapters in the history that unfolds in Mysteries of the Deep. In a series of vignettes ranging f...
Hydrothermal microbial ecosystems
The papers in the "Hydrothermal Vent" e-book cover a range of microbiological research in deep and shallow hydrothermal environments, from high temperature “black smokers,” to diffuse flow habitats and episodically discharging subsurface fluids, to the hydrothermal plumes. Together they provide a snapshot of current research interests in a field that has evolved rapidly since the discovery of hydrothermal vents in 1977. Hydrothermally influenced microbial habitats and communities represent a wide spectrum of geological setting, chemical in-situ regimes, and biotic communities; the classical examples of basalt-hosted black smoker chimneys at active mid-ocean spreading centers have been au...
Deep Subsurface Microbiology
Deep subsurface microbiology is a highly active and rapidly advancing research field at the interface of microbiology and the geosciences; it focuses on the detection, identification, quantification, cultivation and activity measurements of bacteria, archaea and eukaryotes that permeate the subsurface biosphere of deep marine sediments and the basaltic ocean and continental crust. The deep subsurface biosphere abounds with uncultured, only recently discovered and – at best - incompletely understood microbial populations. In spatial extent and volume, Earth's subsurface biosphere is only rivaled by the deep sea water column. So far, no deep subsurface sediment has been found that is entirel...
New Perspectives on State Socialism in China
Placing Chinese Community Party history in the realm of social history and comparative politics, this text studies the roots of the policy failures of the late Maoist period and the tenacity of the CCP.
