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Genome Editing in Neurosciences
This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Perspectives in Zebrafish Research
In the past decade, a small tropical vertebrate fish, zebrafish, has rapidly gained the interest of research laboratories worldwide as a model system. This topic will provide updated perspectives on all fields of zebrafish research from experts gathering at the 5th Zebrafish Principal Investigators Meeting in Trento, 20-23 March 2018. The community of researchers using zebrafish is rapidly expanding, necessitating a clear plan for how to tackle central questions that remain a challenge in the field and providing inspiration for future studies. This is the aim of the workshop and the Frontiers Research Topic will provide a platform for dissemination of novel ideas arising from this meeting.
The Civic World of Early Renaissance Florence
Professor Brucker contends that changes in the social order provide the key to understanding the transition of Florence from a medieval to a Renaissance city. In this book he shows how Florentine politics were transformed from corporate to elitist. He bases his work on a thorough examination of archival material, providing a full socio-political history that extends our knowledge of the Renaissance city-state and its development. The author describes the restructuring of the political system, showing first how the corporate entities that comprised the traditional social order had lost cohesiveness after the Black Death. He traces the process of readjustment that began during the guild regime...
The Society of Renaissance Florence
First published in 1971, The Society of Renaissance Florence is an invaluable collection of 132 original Florentine documents dating from the fourteenth and fifteenth centuries.
Genome Editing in Neurosciences
This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
The world according to zebrafish: How neural circuits generate behaviour
Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.
The Economy of Medieval Hungary
The Economy of Medieval Hungary is the first concise, English-language volume about the economic life of medieval Hungary. It is a product of the cooperation of specialists representing various disciplines of medieval studies, including archaeologists, archaeozoologists, specialists in medieval demography, historical hydrologists, climate and environmental historians, as well as archivists and church historians. The twenty-five chapters of the book focus on structures of medieval economy, different means and ways of human-nature interactions in production, and offer an overview of the different spheres of economic life, with a particular emphasis on taxation, income and commercial activity. ...
