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The Molecular Biology of Physarum polycephalum
One landmark in the long history of biological studies on the "slime mold" Physarum polycephalum was the introduction of chemi cally defined growth conditions for the plasmodial phase of this organism in the laboratory of Harold P. Rusch in Wisconsin in the 1950s. A number of investigators began working with Physarum in that era, then dispersed over the world. In the 1950s to 1960s, the regular meetings of Physarum workers in North America were commonly held in Wisconsin. Strong new scientific initiatives in Physarum have grown up independently, from the disciplines of genetics, cytology, photo biology, and biophysics, in countries scattered over the world from Japan to Poland, Germany, France, the Netherlands, Norway, Spain, Turkey, and Great Britain. Infusion of the technical power of contemporary molecular biology--in particular, gene cloning and monoclonal antibodies--has brought these dispersed investigators into mutual communication. It was therefore timely and appropriate to assemble the Physarum community again in Wisconsin after a hiatus of 20 years, at a conference in the Friedrick Conference Center at the University of Wisconsin, Madison, from July 8 to 13, 1985.
Central and Peripheral Mechanisms of Cardiovascular Regulation
There is increasing awareness that the autonomic nervous system, through its central and peripheral pathways, plays a critical role in the regulation of the circulation. Peripherally, the autonomic representation, largely that of sympathetic nerves, innervate virtually all segments of the vascular tree as well as the adrenal medulla. Through the interaction of nerve terminals, their transmitters, receptors and intracellular mediators in smooth muscle, sympathetic neurons control vascular tone as well as the basal performance of the heart. In turn, the performance of the autonomic nervous system is highly controlled by the brain. Once viewed as a black box with only a vague influence on cardi...
Structure and Dynamics of RNA
This volume contains contributions from the speakers at the NATO Advanced Research Workshop on "3D 5tructure and Dynamics of RNA", which was held in Renesse, The Netherlands, 21 - 24 August, 1985. Two major developments have determined the progress of nucleic acid research during the last decade. First, manipulation of genetic material by recombinant DNA methodology has enabled detailed studies of the function of nucleic acids in vivo. 5econd, the use of powerful physical methods, such as X-ray diffraction and nuclear magnetic resonance spectroscopy, in the study of biomacromolecules has provided information regarding the structure and the dynamics of nucleic acids. Both developments were en...
Cell Biology of Physarum and Didymium V2
Cell Biology of Physarum and Didymium, Volume II: Differentiation, Metabolism, and Methodology summarizes important experimental research using Physarum and Didymium for developmental and cellular studies. This book is organized into three parts, encompassing 28 chapters that cover the differentiation, metabolism, and experimental techniques for cellular studies. After presenting an introduction to some aspects of developmental biology, this volume describes the ultrastructure and physiology of sporulation, spore germination, encystment, excystment, spherulation, and spherule germination. This is followed by a discussion on regulatory events leading to morphogenesis and on biochemical, physi...
Basic and Applied Aspects of Noise-Induced Hearing Loss
In September 1985, NATO sponsored an Advanced Study WOl'kshop entitled, "Noise-Induced Hearing Loss: Basic and Applied Aspects." Tne meeting was held in a mountain retreat near Lucca, Italy and was attended by scientists, clinicians, and public officials from 12 countries. This was the third in a series of such conferences organized by the authors. The first two were supported by the United States National Institute of Occupational Safety and Health; their proceedings were published as "The Effects of Noise on Hearing" in 1976 and "New Perspectives on Noise-Induced Hearing Loss" in 1982. The Organizing Committee approached NATO because it was felt that the problem of noise was common to all ...
Targeting of Drugs With Synthetic Systems
Targeting of drugs via carrier systems to sites in the body in need of pharmacologic intervention is a rapidly growing area of research in the treatment or prevention of disease. It has evolved from the need to preferentially deliver drugs, enzymes, vitamins, hormones, antigens, etc. to target cells and organs so as to avoid toxicity, waste of drugs through premature secretion or inactivation and at the same time render treatment more convenient and cost-effective. A wide assortment of naturally occ urring or semi-synthetic drug carriers (e. g. antibodies, glycoproteins, lectins, peptide hormones, cells and liposomes), their inter action with relevant receptors and mediation of optimal pharm...
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Growth and Differentiation in Physarum Polycephalum
Physarum polyccphalum is commonly referred to as a true slime mold, or myxomycete. Providing a basic foundation for the latest work in the cell and developmental biology of true slime molds, these critical essays review five areas of research: nuclear structure, replication, expression, genetics, and differentiation. Originally published in 1980. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
