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Aspects of Louisbourg
Aspects of Louisbourg is an eclectic collection of essays that considers the economic, social, military, and commemorative events in the lives of the people of Louisbourg. From the rugged life of an 18th -century fishing family, to gardens and material culture, to today's commemorative activities, these essays paint a picture of the life of Louisbourg.
Archivaria
None
Frontiers in Anti-Cancer Drug Discovery, Volume (1)
"Frontiers in Anti-Cancer Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug di
The Oncogenomics Handbook
An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.
Gynecologic Oncology
In recent years, there have been major advances in the treatment of patients with gynecologic malignancies. Perhaps the biggest advances have been in the area of ovarian cancer. Gynecologic Oncology focuses primarily upon this malignancy. This volume discusses cytoreductive surgery; screening for ovarian cancer; chemotherapy; new chemotherapeutic drugs; the controversy regarding the role of high-dose chemotherapy in gynecologic cancers; the hereditary basis for gynecologic malignancies; molecular genetics; molecular biology and new biologic therapies. Other topics covered are the treatment of all stages of cervical cancer, including radiotherapy. In addition, a chapter on advances in the pathology of gynecologic cancers is included. The advances made in the treatment of gynecologic malignancies are due, in part, to the clinical studies performed by many of the contributors to this volume. Clinical advances have been the result of multidisciplinary approaches which involve molecular biologists, pathologists, radiation therapists, surgeons and chemotherapists. Future advances will continue to rely upon collaborative interaction among these different disciplines.
Vascular Disruptive Agents for the Treatment of Cancer
Angiogenesis (formation of new vessels from pre-existing ones) is a crucial early event in the process of tumor development. New vessels supply the tumor with nutrients that are needed for further local growth and enable distant metastases (Folkman 1995). Judah Folkman (1971) highlighted the potential therapeutic imp- cations of tumor angiogenesis. He hypothesized that if tumor angiogenesis is inhibited, then tumor growth and metastasis will be impaired greatly or even impossible. The subsequent quest for endogenous and exogenous inhibitors of angiogenesis has yielded a variety of promising therapeutic agents that block one or more angiogenic pathways, a few of which have been approved by th...
Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds
The modern unhealthy diet and lifestyle in conjunction with pathogens, environmental carcinogens and multiple other risk factors increase humans’ susceptibility to different diseases exemplified by elevated levels of cancers, cardiovascular and communicable diseases. Screening of potential drugs from medicinal plants and animals provides a promising strategy for the alleviation of the impact of these diseases. Components with potential medicinal applications include RIPs, RNases, lectins, protease inhibitors and numerous small compounds. These compounds have shown both preventive and therapeutic effects for humans. This book is a compilation of articles written by internationally renowned experts exploring the different uses of medicinal compounds in human therapeutics. Here we provide a comprehensive outlook on both qualitative and quantitative studies focusing on medicinal plants and animals, and establishing a link between laboratory research discovery and clinical applications.
Current Catalog
Includes subject section, name section, and 1968-1970, technical reports.
From Migrant to Acadian
Despite their position between warring French and British empires, European settlers in the Maritimes eventually developed from a migrant community into a distinctive Acadian society. From Migrant to Acadian is a comprehensive narrative history of how the Acadian community came into being. Acadian culture not only survived, despite attempts to extinguish it, but developed into a complex society with a unique identity and traditions that still exist in present day Nova Scotia and New Brunswick.
Architecture and Town Planning in Colonial North America
Incorporating more than 3,000 illustrations, Kornwolf's work conveys the full range of the colonial encounter with the continent's geography, from the high forms of architecture through formal landscape design and town planning. From these pages emerge the fine arts of environmental design, an understanding of the political and economic events that helped to determine settlement in North America, an appreciation of the various architectural and landscape forms that the settlers created, and an awareness of the diversity of the continent's geography and its peoples. Considering the humblest buildings along with the mansions of the wealthy and powerful, public buildings, forts, and churches, Kornwolf captures the true dynamism and diversity of colonial communities - their rivalries and frictions, their outlooks and attitudes - as they extended their hold on the land.
