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HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies
  • Language: en
  • Pages: 171

HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies

Multiple dysfunctions take place in the B cell compartment during HIV-1 infection, comprising depletion of resting memory B cells carrying serological memory to vaccines and previously met pathogens. In addition, population of B cells characterized by the expression of exhaustion markers are enlarged during HIV-1 infection. Antibodies with the capacity to neutralize a broad range of HIV-1 isolates can be detected only in a minority of infected patients, after a year or more from acute infection. An open question is whether the inability of producing neutralizing HIV-1 antibodies is somehow linked to the B cell immunopathology observed in patients. In this research topic we invited scientists...

The Neurology of AIDS
  • Language: en
  • Pages: 894

The Neurology of AIDS

The Neurology of AIDS is a compilation of works addressing six major aspects of nervous system disease that commonly follows HIV-1 infection. This includes basic science; clinical science; neuropathology; therapy; neuropsychiatric and prospectives of disease provided by patients.

Lymph Node T Cell Dynamics and Novel Strategies for HIV Cure
  • Language: en
  • Pages: 186

Lymph Node T Cell Dynamics and Novel Strategies for HIV Cure

Currently, more than 36 million people are infected with HIV. Although the introduction of highly active anti-retroviral therapy (HAART) has led to substantial advances in the clinical management of HIV infected individuals, HAART cannot completely eliminate the virus. This is because CD4 T helper cells, harboring the virus, remain dormant reservoirs. These reservoirs are difficult to measure and are present even in HAART-treated HIV infected individuals with undetectable levels of HIV in the blood. A growing body of studies has revealed follicular helper (Tfh) CD4 T cells, a highly differentiated CD4 T cell population localized in immunologically sanctuary sites (follicle/germinal center), ...

Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response
  • Language: en
  • Pages: 1671

Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response

Volume I.A An outbreak of a respiratory disease first reported in Wuhan, China in December 2019 and the causative agent was discovered in January 2020 to be a novel betacoronovirus of the same subgenus as SARS-CoV and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) has rapidly disseminated worldwide, with clinical manifestations ranging from mild respiratory symptoms to severe pneumonia and a fatality rate estimated around 2%. Person to person transmission is occurring both in the community and healthcare settings. The World Health Organization (WHO) has recently declared the COVID-19 epidemic a public health emergency of international ...

Official Gazette of the United States Patent and Trademark Office
  • Language: en
  • Pages: 908

Official Gazette of the United States Patent and Trademark Office

  • Type: Book
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  • Published: 1995
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  • Publisher: Unknown

None

III International Conference on Acquired Immunodeficiency Syndrome (AIDS)
  • Language: en
  • Pages: 252

III International Conference on Acquired Immunodeficiency Syndrome (AIDS)

  • Type: Book
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  • Published: 1987
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  • Publisher: Unknown

None

Current Catalog
  • Language: en
  • Pages: 1120

Current Catalog

  • Type: Book
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  • Published: Unknown
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  • Publisher: Unknown

First multi-year cumulation covers six years: 1965-70.

National Library of Medicine Current Catalog
  • Language: en
  • Pages: 1128

National Library of Medicine Current Catalog

  • Type: Book
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  • Published: 1990
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  • Publisher: Unknown

None

AIDS Research and Human Retroviruses
  • Language: en
  • Pages: 618

AIDS Research and Human Retroviruses

  • Type: Book
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  • Published: 1997
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  • Publisher: Unknown

None

AIDS Research at EC Level
  • Language: en
  • Pages: 396

AIDS Research at EC Level

  • Type: Book
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  • Published: 1995
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  • Publisher: IOS Press

At EC level the fight against AIDS, one of the major health problems and socioeconomic diseases today, is also part of the specific RTD programme in the field of biomedicine and health. About 600 research teams are collaborating within 30 concerted actions networks that are underpinned by centralised facilities. For example, the epidemiology research networks are monitored by the WHO/EC collaborating centre in St. Maurice, France. Common experiments on animal models, antiviral screening, genetic analysis of multiple virus strains and provision of reagents for vaccine development are also centralized facilities in AIDS research carried out under the principles of subsidiarity and Community ad...