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Molecular and Cell Biology of Type 2 Diabetes and Its Complications
The present volume summarizes current research on type 2 diabetes, its etiology, pathogenesis and long-term vascular and neurological consequences, with special emphasis on molecular and biochemical mechanisms. Alterations in insulin secretion are comprehensively treated, focusing on the role of glucokinase as glucose sensor. Moreover, insulin action is analyzed with regard to both nonoxidative glucose utilization and glucose oxidation. Concerning the complications in chronic diabetes, topics covered include the effects of high glucose concentration on cellular and endothelial functions and on the glucose phosphorylation rate in non-insulin-sensitive tissues. Furthermore, the role of oxidati...
Words and Deeds in Renaissance Rome
The social historian, searching for the basis of a culture, often turns to a study of ordinary people. Perhaps one of the most revealing places to find them is in a court of law. In this presentatoin of nine criminal trials of sixteenth-century Rome (1540-75), where magistrates kept verbatim records, Thomas and Elizabeth Cohen paint a lively portrait of a society, one that is reminiscent of Boccaccio. These stories, however, are true. Each trial transcript is followed by an essay that interprets the beliefs, codes, everyday speech, and personal transactions of a world that is radically different from our own. The people on trial include assassins, a spell-caster, an exorcist, an adulterous wife, several courtesans, and the peasant cast of a bawdy, sacrilegious play. Out of their often pognant troubles, and their machinations, comes a vivid revelation of not only the tumultuous street life of Rome but also rituals of honour, the power and weakness of women, and the realities of social and economic hierarchies. Like cinema-verite, Words and Deeds in Renaissance Rome gives us an intimate glimpse of a people and their world.
Oxygen Transport to Tissue XXXII
This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology.
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Klinefelter’s Syndrome
This book presents the latest insights into all the critical aspects of Klinefelter’s Syndrome, in order to promote a more homogeneous a medical approach to this condition, leading to better and more “evidence-based” support, and improving patient satisfaction. It offers physicians and all health professionals involved in treating these patients (andrologists, pediatricians, endocrinologists, psychologists) a comprehensive overview and a useful tool for their daily clinical practice.
Defining and Protecting Autonomous Work
This book, adopting a multidisciplinary approach, investigates the definition of autonomous work and the kind of protection it receives and should receive in a global perspective. The book advocates for the existence of genuine autonomous work to be distinguished from employment and false self-employment. It deserves specific attention from legislators in the view of removing any obstacles to the exercise of freedom of association and collective action at large. The book is divided into two parts. The first focuses on the evolving notion of autonomy and its consequences on social protection, offering a theoretical frame from an organizational, political and legal point of view. The second aims at discovering new regulatory and protective horizons for autonomous work, in the light of blockchain, platform work, EU Competition Law, social security and liberal professions. Finally, the authors offer insights and recommendations on how to protect work beyond categories.
Oxygen Transport to Tissue XL
The book contains the refereed contributions from the 45th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) 2017. This volume covers cross-disciplinary work on a broad range of topics related to the dynamics of oxygen transport: microcirculation and vascular medicine; O2 deficiency and its impact on molecular processes in cells and tissues; cellular metabolism and mitochondrial function; multimodal functional imaging; mathematical modeling; the clinical relevance of oxygen supply as well as therapeutic interventions (e.g. in oncology or critical care medicine). The annual meetings of ISOTT bring together scientists from diverse fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. The book includes sections on brain oxygenation and function, NIRS oxygenation measurements, tumor oxygenation, cell metabolism, tissue oxygenation and treatment, methodical aspects of O2 measurements and physicochemical aspects of oxygen diffusion. Chapters 3, 24, 49 and 51 of this book are open access under a CC BY 4.0 license.
Muscle Metabolism
Diabetes research on models comprising intact animal tissues, cell cultures and isolated pancreatic islets is essential for understanding the pathogenesis of the disease as well as the mechanisms responsible for the chronic complications associated with it. Enormous advances in the understanding of the development of diabetes and its prevention hav
