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Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
This accessible textbook offers balanced and uniformly excellent coverage of modern linguistics.
Comprehensive and accessible coverage from the basics to advanced topics in modern quantum condensed matter physics.
This revised edition of the popular reference and textbook outlines the historical developments in computing technology. It explains and describes historical aspects of calculation with an emphasis on the physical devices used in different times to aid people in their attempts at automating the process of arithmetic.
A Grammar of Modern Indo-European is a complete reference guide to a living Indo-European language. It contains a comprehensive description of Proto-Indo-European grammar, and offers an analysis of the complexities of the prehistoric language and its reconstruction from its descendant languages. Written in a fresh and accessible style, and illustrated with maps, figures and tables, this book focusses on the real patterns of use of Late Indo-European. The book is well organised and is filled with full, clear explanations of areas of confusion and difficulty. It also contains an extensive English - Indo-European, Indo-European - English vocabulary, as well as detailed etymological notes, designed to provide readers with an easy access to the information they require.An essential reference source for the student of Indo-European as a learned and living language, this work will appeal to students of languages, classics, and the ancient world, as well as to general readers interested in the history of language, and in speaking the direct ancestor of the world's largest language family.
This publication examines how opening sequences in films, classic and contemporary, act as hooks to draw the viewer into the film, showing frame by frame how graphics, type and animation are used to create atmosphere, set tone, and lend impact to movies. From Hitchcock and Godard to Tarantino, Luc Besson, and Tim Burton, this large format coffee table book finally illuminates this critical role designers play in filmmaking and gives credit to those that often go uncredited.
What is the appropriate way to taste wine at a restaurant? What type of wine is best served with catfish? 1000 Best Wine Secrets contains all the information novice wine drinkers and experienced connoisseurs alike need to feel comfortable in any restaurant, home or vineyard. 1000 Best Wine Secrets is the book for readers seeking the confidence to select and enjoy the perfect bottle from among the wines of the world. Includes such tips as: Secrets of buying great wine Detecting faulty wine and sending it back Serving wine like a pro Wine tips from around the globe—from Argentina to France and Spain to California Knowing when to drink wine
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Should Anne risk arrest and scandal to help a fugitive escape? Her decision will change her life. In 1628, with England torn by conflict, fifteen-year old Anne Dudley helps a rebel escape from Tattershall Castle through the watery fens. Pursued by the sheriff and his men, who view her Puritan family as traitors to the king, Anne risks more than the loss of her reputation as the daughter of the earl's steward - she also risks death. Set in a period when women and men were burned or hanged for their religion, the novel tells the story of a girl who must cope with a woman’s feelings while she struggles with romantic turmoil, political danger, and doubts about her own beliefs. When she takes up her pen, we glimpse the grown Anne Dudley Bradstreet, whose Colonial writings are still loved and honored today. From a talented new voice in historical fiction, Gretchen Gibbs’ Anne of the Fens joins The Book of Maggie Bradstreet in The Bradstreet Chronicles. Records about the author's well-known ancestors give birth to her stories. Read the series—enriched by the historical content in each book's back pages—in any order.
This text reorganizes the traditional material according to the five major perapectives in the field: biological; learning; cognitive; socio-cultural and psychodynamic. It offers a presentations of each perspective's strengths, limitations and misuses.