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Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System
Proteolysis by the ubiquitin-proteasome pathway (UPP) in the nervous system has been extensively studied both in the context of normal physiological function as well as abnormal pathological conditions. Although ubiquitin was used as a marker of brain pathology, the normal functions of the UPP were not studied much in the nervous system until the 1990s. The early investigations focused on synaptic plasticity which was followed by studies on the roles of protein degradation in the development of the nervous system. Research on the role of abnormal roles of the UPP follows a parallel trajectory. Since the 2000s, the field has grown to encompass many subareas of research and several model syste...
Current Catalog
First multi-year cumulation covers six years: 1965-70.
The Human Hypothalamus in Health and Disease
The Human Hypothalamus in Health and Disease
Vasopressin
The concept for Vasopressin: Principles and Properties originated during the sum mer of 1983. From reviewing the rich and diverse literature on vasopressin, it became evident that the rapid advancements in this field made it difficult to syn thesize the information gathered from divergent scientific disciplines into a coherent view of the biological role of vasopressin. We perceived the need for a series of critical reviews delineating this recent progress. Over the past decade, major advances have been made in studies of the anatomy, physiology, phar macology, molecular biology, and behavioral activities of vasopressin. This is, in no small measure, due to the finding that vasopressin can n...
Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy
This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regene...
