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The Warburg Effect Regulation Under Siege: The Intertwined Pathways in Health and Disease
Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.
Antisense Technology, Part B: Applications
Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods which inhibit gene expression permit studies probing the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedically-oriented research.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.
PATH - Proliferation-Accumulation-Tumor-Hypothesis
What is or what does a gene mutation do? A gene mutation, i.e. the damage of a gene, leads to a gene expressing more, less or modified proteins. These altered proteins alter the behaviour of the cell. And this is how cancer is ultimately to develop: Changed proteins due to changes in the genes. But what would happen if these changes in the proteins were not caused by mutations in the genes, but by direct damage to the proteins? Then the result "cancer" would be the same, but otherwise everything would be different. And cancer could be curable. We cannot reverse a mutation, but we can reverse a mechanical process such as protein accumulation. At least we could considerably influence such a ca...
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