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The Blood Brain Barrier and Inflammation
This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.
Organic Service-Level Management in Service-Oriented Environments
Dynamic service-oriented environments (SOEs) are characterised by a large number of heterogeneous service components that are expected to support the business as a whole. The present work provides a negotiation-based approach to facilitate automated and multi-level service-level management in an SOE, where each component autonomously arranges its contribution to the whole operational goals. Evaluation experiments have shown an increased responsiveness and stability of an SOE in case of changes.
Metallic Biomaterial Interfaces
Clearly divided into three sections on the interface influence of materials and surface modifications, the physical and physicochemical surface characterization, and the biological characterization of the interface and biosystem reactions, this book is the first to concentrate on the highly important area of metal-based implants and their improved functionality and acceptance by the body.
The Wuerttemberg Emigration Index
Contains names of approximately 60,000 persons applied to leave Germany from late eighteenth century to 1900. Includes date & place of birth, residence at time of application & application date.
Complex Behavior in Evolutionary Robotics
Today, autonomous robots are used in a rather limited range of applications such as exploration of inaccessible locations, cleaning floors, mowing lawns etc. However, ongoing hardware improvements (and human fantasy) steadily reveal new robotic applications of significantly higher sophistication. For such applications, the crucial bottleneck in the engineering process tends to shift from physical boundaries to controller generation. As an attempt to automatize this process, Evolutionary Robotics has successfully been used to generate robotic controllers of various types. However, a major challenge of the field remains the evolution of truly complex behavior. Furthermore, automatically create...
Entering History
This book offers a thorough examination of the novels of Irmtraud Morgner (1933-1990), one of the most talented, compelling and overlooked writers within East German feminist and avant-garde circles. Using a combination of theoretical approaches - including Adorno's aesthetic theories and Bakhtinian analyses of dialogism and the carnivalesque - the author traces Morgner's engagement with postmodernist aesthetic strategies back to her efforts, beginning in the early 1970s, to pose questions about effective political practices. Morgner's work sheds new light on the fraught relationship between GDR intellectuals and the state, a hotly debated topic that marks most recent attempts to understand literary culture in the German Democratic Republic. Situating Morgner's fiction at the intersection of postmodern and feminist theory, this study also offers new evidence for viewing literature from the GDR as significantly more complex and aesthetically interesting than has been previously assumed.
Häuser und Familien in Demmin
Nur wenig erinnert noch heute an die umfangreiche Häuser- und Familiengeschichte von Demmin, da fast alle Häuser aus der älteren Zeit bei den zahlreichen Stadtbränden zerstört worden sind. Es entstand die Idee, ein Häuserverzeichnis von Demmin anzulegen, um auch mehr über die Familien zu erfahren, die einst in Demmin lebten. Nicht nur die Lebensdaten der einzelnen Personen sind für die Familienforschung interessant, sondern auch alle Informationen, die man über die Häuser zusammentragen kann. Dieser Bereich der Ortsforschung wurde bislang nur wenig in den Stadtchroniken von Demmin behandelt. Als Hauptquelle für die nachfolgende Publikation dienen die 6 Hypothekenbücher der Stadt Demmin aus der Zeit um 1770–1865 (mit einzelnen Nachträgen bis 1866) und verschiedene Akten aus dem Landesarchiv Greifswald und dem Demminer Museumsbestand. Ebenfalls wurden, sofern vorhanden, Fotografien ergänzt. Tauchen Sie ein in ein Kapitel der Demminer Häuser- und Familiengeschichte aus der Zeit von 1625 bis 1865! Über 1700 verschiedene Familiennamen und über 700 Häuser warten darauf, entdeckt zu werden.
