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Oligonucleotides modulate gene-specific expression within cells and can be used to identify genes involved in diseases. Continuing developments in oligonucleotide research have begun to unleash their potential as therapeutic agents. Contributions from basic researchers in molecular biology, cell biology, nucleic acid chemistry, pharmacology, and applied therapeutics present new technologies in the field of oligonucleotide research and are organized into sections focusing on small RNA-mediated gene silencing, miRNA, oligonucleotide chemistry and new technologies, delivery strategies, immunorecognition of nucleic acids, drug and therapeutic development, aptamers and other evolved systems, and ...
Waffen-SS Armour in Normandy presents the combat history of SS-Panzer Regiment 12 and SS-Panzerjäger Abteilung 12 in the Battle for France from June to the end of August 1944 based on transcriptions of their original unit war diaries from the Military History Archives in Prague. Both armored units belonged to the 12.SS-Panzer Division Hitlerjugend. SS-Panzer Regiment 12 was fully equipped with Panzer IV and Panther tanks. The main AFV of SS-Panzerjäger Abteilung 12 was the Jagdpanzer IV L/48 tank destroyer. The structure of the volume is partly source publication (documents of SS-Panzer Regiment 12) and partly study (the deployment of SS-Panzerjäger Abteilung 12). The text was written and...
Recent developments in concepts and techniques have brought enzyme research to a changing yet exciting stage. Enzymes have served as indispensable tools in the phenomenal rise of molecular biology, and the resultant biotechnology thrusts enzymes to new heights and territories. This volume, the proceedings of a recent symposium on the Dynamics of Soluble and Immobilized Enzyme Systems, provides a current overview of the field to help scientists utilize long-established and newly acquired information.
Occultism and the Origins of Psychoanalysis traces the origins of key psychoanalytic ideas back to their roots in hypnosis and the occult. Maria Pierri follows Freud’s early interest in "thought-transmission," now known as telepathy. Freud’s private investigations led to discussions with other leading figures like Carl Jung and Sándor Ferenczi, with whom he held a "dialogue of the unconsciouses." Freud’s and Ferenczi’s work assessed how fortune tellers could read the past from a client, inspiring their investigations into countertransference, the analytic relationship, unconscious communication, and mother-infant relationality. Both Freud and Ferenczi tried in different ways to come...
Part two of the defining work on Hitler's elite fanatical boy soldiers continues with the survivors of the bloody fighting in France regrouping to make a final stand in the Ardennes and Hungary before Germany was overcome by the Allies. A detailed and gripping account of the most famous, and infamous, division to fight in World War II for any side.
This book reviews in a concise and manageable way the progress in all key areas of natural products chemistry since 1984. The most significant advances are highlighted over a wide field of chemistry, structure, synthesis and biosynthesis. This book provides a unique and superb entry into the vast literature on the subject.
With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.
This is an essential bench book that describes the molecular biology, structure, detection, purification, and pathogenesis of viroids and satellites. The volume begins with an overview of the current status of the field, followed by four chapters describing details of methodology, nucleic acid probes, purification, sequence variation, complementary RNA probes, polyacrylamide gel electrophoresis and mutational analysis of viroid movement and pathogenicity. Remaining chapters discuss such topics as viroids that cause apple scar disease in China, the cadang-cadang disease of palms in the Pacific area, viroid-like satellite RNAs, and a comparison of plant viroids with the human-pathogenic delta agent. The book will be a major reference work on viroids for years to come and an essential resource for virologists, molecular biologists, microbiologists, geneticists, biochemists, biomedical investigators, plant pathologists, and agricultural researchers.
A case-study of the origins of working-class radicalism in Imperial Germany.
The concept of a blood retinal barrier is still relatively new in the ophthalmic literature. fuereas work on the blood-brain barrier was initiated in the first decade of this century, the blood retinal barrier has only recently been defined. Information accu mulated during the last 10 years has shown that the function of the blood-ocular barriers may be better understood if two main barrier systems are considered to exist in the eye. The blood-aqueous barrier regulates the exchanges between the blood and the intraocu lar fluids, and the blood-retinal barrier separates the neural tissue from the blood. Recent studies have shown that the blood-retinal barrier plays a fundamental role in contro...