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Behind a great medical drug there is always a great scientist!
Medical drugs are more than just compressed powder or bitter syrups. They are life saviour and one of the best rewards of a career in research. Did you know that behind any drugs there are amazing stories and incredible adventures of inspiring people that have dedicated their life to it? In this collection, we will be looking at what does it take to discover a medical drug while exploring the life and journey of many scientists (and not) that have played a fundamental role in their creation. From the use of opium (a plant latex containing morphine) by the Sumerians in 5000 B.C. to the discovery of receptors (molecules that bind drugs) through colouring of biological tissues (Paul Ehrlich, 18...
Infinity
The most important and known world faith traditions of humankind have similar spiritual values and share many aspects of belief, culture, and ritual. In Infinity, author Minerva speaks to those who understand the importance of oneness and unity despite the diversity in spiritual beliefs. The reverence for the infinite, the universal God of your heart, the wanting and promoting the need for collective unity, love, peace, and respect for life is across the foundation and the shared belief of all religions. Based on her personal experiences and spiritual journey, she offers inspiring twirls of rhyme, invocations, magical prayers, positive verses, devotional hymns, and everyday common positive m...
Scents that matter - from olfactory stimuli to genes, behaviors and beyond
Scents can carry a lot of important information about the environment, conspecifics and other species. While some of these scents are positively related, as the odor of food, mating partners, or familiar conspecifics, other scents are associated with negative situations and events, e.g. the occurrence of a predator, an aggressive territorial conspecific or spoiled food. The present research topic is focused on such “scents that matter”, i.e., scents that are crucial for the survival of an organism. Since many years, the importance of scents always attracts scientists to investigate how scents affect the behavior of mammals, via which mechanisms scents are perceived and how scents modulat...
Engaging with Emotion
This work informs by encouraging the reader to interact with the text itself and with the literature in the area. It is a learning tool rather than an encyclopaedic presentation of its topic. The writing style is personal, direct and accessible. Citations are employed, but always for specific purposes. Cited materials are made accessible whenever possible by the provision of URLs. Readers learn about emotion and its relationship to brain, body, cognition, memory, and appraisal. They are also introduced to the role of emotion in language and in the fine arts. Readers of Engaging with Emotion will likely be students within the first two years of university or college taking a related course, or those who are interested in learning more about emotion. This book is ideal for adaptation to an online course format as it includes exercises and learning guides. The book uses straightforward and helpful language and examples to avoid frustrating or confusing students, but instead to keep them actively involved with the material in the book, and to help motivated learners learn.
Vascular Inflammation in Systemic Autoimmunity
Plasticity and dynamism characterize the immune system as a tissue-integrating network with defensive functions. Blood and lymphatic vessel trees constitute the most evident and intuitive physical platform for the development of the net of interactions between immune cells, body tissues and foreign agents. Moreover vessel repair and immune patrolling are intimately linked physiological functions with common evolutionary roots. Not surprisingly variable degrees of vascular inflammation are often detectable in the setting of systemic inflammation and autoimmunity, whereas research in the field of cardiovascular pathology is progressively converging towards the identification of a common inflammatory background. The definition of the role of vascular inflammation in causing, sustaining and/or predicting the development of systemic autoimmunity constitute a challenging, unexplored frontier towards the development of a new generation of treatments and a better patient care.
Macrophages in inflammation and its resolution
Macrophages were initially identified as a key element in the innate host response to infection and injury due to their phagocytic clearance and elimination of pathogenic and non-pathogenic entities. However, as macrophage research advanced it became clear that not only are these cells amenable to the acquisition of multiple plastic phenotypes during inflammatory responses to different pathogens, they also play a paramount role in the termination of inflammation and acquired immune responses. In addition, macrophages profoundly affect host physiology when they migrate to distant sites and differentiate to specialized cells, like foam cells, osteoclasts, adipose tissue- and tumor -associated ...
Role of Natural Compounds in Inflammation and Inflammatory-Related Diseases
The papers reported here will contribute to proposing new insights into the mechanisms of several conditions, as well as suggesting new diagnostic alternatives and therapeutic targets in widespread pathologies such inflammation and inflammatory-based diseases. The discovery of the new is, as always, anchored in recourse to the old.
The Physiology of Inflammation – The Final Common Pathway to Disease
Chronic diseases are increasingly recognized as involving low grade inflammation, that is, a self-perpetuating tissue response to stress caused by exogenous or endogenous triggers, that progressively evokes danger-associated molecular pattern release, ultimately driving tissue damage and loss of function. This response is frequently unapparent clinically, thus the designation "low grade". This eBook comprises nineteen reviews and original articles that provide the most updated knowledge on the causes and roles of this inflammatory response in a variety of diseases and conditions. The editorial that precedes these articles not only summarizes each one, but provides a broader interpretation of the role of inflammation in health and a variety of disease conditions, the underlying mechanisms and the targets more promising for therapy. Finally, it also highlights the most relevant and emerging research topics that are already shaping future directions for the development of more fine-tuned and innovative therapies.
