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Ontogeny of Olfaction
The impacts of specifically experienced external and internal environments upon phylogenetically established pathways of ontogenetic development seem to be responsible for the intra-species variation of organisms. Therefore normal function, as well as disorders of sensory systems, can often be better understood by considering the principles of ontogenetic maturation and the time schedule of environmental influences during that period. Sensory organs and systems have long been considered to be hereditally determin ed for their analysis of the environment. However, it is becoming more and more clear that their specificity depends also upon the sequence and nature of environ mental impacts, imp...
Cell Biology of Olfaction
The sense of smell is probably the most important sense to a large number of the animal species on Earth and the aim of the study of olfactory cell biology is to understand the cellular basis on which olfactory-driven behaviour is based. In this book the author presents a critical analysis of what is known about the olfactory sensory cells in both the nasal cavity and the vomeronasal organ. Although the emphasis is on mammalian olfaction, basic issues that have been addressed by research on other vertebrates and invertebrates are also discussed. Throughout the book the premise is that we can only more thoroughly comprehend normal behaviour and dysfunction once we have a detailed understanding of the cells and tissues involved in the sense of smell.
Stem Cells and CNS Development
Stem Cells and CNS Development critically reviews recent findings on stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. It defines by consensus the classes of stem cells in the nervous system, compares their similarities and differences, discusses the gains made in identifying human homologs of neural stem cells, and describes how these cells are beginning to be used for therapeutic purposes. Comprehensive and cutting-edge, this book provides all developmental scientists and neurobiologists not only an authoritative account of the current results in neural stem cell research, but also an incisive review of the rapidly emerging therapeutic uses of stem cells.
Neural Development and Stem Cells
This expanded and updated edition reflects the enormous increase in our knowledge of the development of the nervous system and the use of neural stem cells in clinical applications. Integrating new information about the use of development of neural stem cells for clinical applications, Drs. Rao, Carpenter and Vemuri have added additional chapters on neural transplantation and development of neural stem cells using reprogramming technologies. A new chapter on cancer in nervous system delineates how the fundamental biology of neural stem cells informs our understanding of cancer and tumor formation in the nervous system. Special attention is paid to the derivation of neural cells from embryonic stem cells and induced pluripotent stem cells. Authoritative and up-to-date, Neural Development and Stem Cells, 3rd Edition provides neuroscientists with a handy guide to stem cells in the nervous system, tracing with great clarity the development of stem cells from differentiation to neurons, astrocytes, and oligodendrocytes.
Molecular Neurobiology of the Olfactory System
The sense of smell and the olfactory system have been a subject of intrinsic interest for millenia. Inquiry into the structure and function of the olfactory system is based on a long tradition that dates back at least to the ancient Greeks. The mechanistic basis for the sensitivity and selectivity of this chemosensory detection system has always posed a challenge and remained largely a mystery. Recently, there has been a renaissance of interest in it and especially in the application of contemporary techniques of biochemistry and cellular and molecular biology. In this volume, current research utilizing these ap proaches is discussed in depth by a group of scientists who are among the current leaders in the applications of these techniques to the olfactory system. These authors address a wide range of questions that bear directly on the olfactory system but have broader biological implications as well. The various chapters have been grouped into five broad subject areas that emphasize diverse but related questions. "Transduction and Ligand-Receptor Interactions" considers the biochemical bases of stimulus access, interaction, transduction, elimination, and information processing.
Neural Transplants
The story of mammalian neural transplantation really begins eighty-one years ago. In Chicago in December of 1903, a 34-year-old physician, Elizabeth Hopkins Dunn, working as a research assistant in neurology, initiated a series of experiments to examine the ability of neonatal rat cerebral tissue to survive transplantation into the brain of matched littermates. Out of 46 attempts, four clearly successful grafts were identified. The publication of Dunn's results in 1917, the first credible report to demonstrate the feasibility of mammalian CNS transplants, generated little interest. In fact, the next significant experiment in this field did not appear until 1930. The field continued to grow s...
On the Nature of Human Plasticity
This book questions the extent to which human beings are capable of changing their physical characteristics and behavioural patterns.
Model Systems of Development and Aging of the Nervous System
The last decade has generated a multitude of studies using in vitro model systems to explore growth and differentiation of the nervous system. Although the findings have been exciting and have revealed unique properties of neural cells, considerable concern continues to be expressed regarding the significance of in vitro findings in terms of their applicability to in vivo biological events. To examine this issue further, a group of scientists pre sented and discussed their findings at a conference sponsored by the Institute of Developmental Neuroscience and Aging held in Crete, Greece, 26-29 May 1985. The conference was cosponsored by the University of Crete and was generously supported by t...
