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Symmetry in Inorganic and Coordination Compounds
This book addresses the nature of the chemical bond in inorganic and coordination compounds. In particular, it explains how general symmetry rules can describe chemical bond of simple inorganic molecules. Since the complexity of studying even simple molecules requires approximate methods, this book introduces a quantum mechanical treatment taking into account the geometric peculiarities of the chemical compound. In the case of inorganic molecules, a convenient approximation comes from symmetry, which constrains both the electronic energies and the chemical bonds. The book also gives special emphasis on symmetry rules and compares the use of symmetry operators with that of Hamiltonian operators. Where possible, the reactivity of molecules is also rationalized in terms of these symmetry properties. As practical examples, electronic spectroscopy and magnetism give experimental confirmation of the predicted electronic energy levels. Adapted from university lecture course notes, this book is the ideal companion for any inorganic chemistry course dealing with group theory.
Antibacterial Agents
Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of...
Prostatitis and Its Management
This book provides comprehensive coverage of the current and emerging management of prostatitis, from diagnosis to therapy. It addresses all clinical aspects of the prostatitis syndrome and equips the reader with all the information needed to offer a tailored therapy. Furthermore, clinical implications of the disease are analyzed and discussed, with particular attention to andrological complications (infertility) and the possible link between prostatitis and prostate cancer. Special consideration is also given to contemporary aspects of prostatitis management relating to antibiotic stewardship and elevated PSA, bearing in mind that thoughtless treatment of prostatitis represents malpractice and sometimes even a forensic issue. The final chapter comprising questions and answers will be valuable for quick consultation in everyday clinical practice. This book will be a truly practical guide for physicians involved in the diagnostic work-up and treatment of patients suspected of having prostatitis and will also serve as a ready source of information for all physicians who occasionally see prostatitis patients.
The DNA Damage Response: Implications on Cancer Formation and Treatment
The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal...
In Vivo Models of Inflammation
In Vivo Models of Inflammation (Vol. 1) provides biomedical researchers in both the pharmaceutical industry and academia with a description of the state-of-the-art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first, describing and updating the standard models that are most utilized for specific disease areas. New models are included exploring emerging areas of inflammation research.
A New Model for Analyzing Antimicrobial Peptides with Biomedical Applications
Annotation This book is aimed at two audiences. First, it will present evidence for the earthworm's immune system. Second, the results strongly suggest that certain molecules of the earthworm's immune system may be exploited as natural antibiotics--thus the biomedical applications. There are two advantages for using earthworms. First, they are an inexpensive, non-controversial invertebrate model. Second, in contrast to other invertebrates (e.g. Drosophila, C elegans) they are essential for maintaining the integrity of soil. Earthworms have a highly effective immune system since cancer cannot be induced in them nor does it seem to occur in natural populations. Cytotoxicity of cancer cells has...
Life, Death, and Consciousness in the Long Nineteenth Century
This book explores how the writers, poets, thinkers, historians, scientists, dilettantes and frauds of the long-nineteenth century addressed the “limit cases” regarding human existence that medicine continuously uncovered as it stretched the boundaries of knowledge. These cases cast troubling and distorted shadows on the culture, throwing into relief the values, vested interests, and power relations regarding the construction of embodied life and consciousness that underpinned the understanding of what it was to be alive in the long nineteenth century. Ranging over a period from the mid-eighteenth century through to the first decade of the twentieth century—an era that has been called the ‘Age of Science’—the essays collected here consider the cultural ripple effects of those previously unimaginable revolutions in science and medicine on humanity’s understanding of being.
Macrocycles in Drug Discovery
This series provides a comprehensive resource for postgraduate students and for scientists in academia or industry wanting to learn topics outside their own areas of expertise.
