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Cancer
This volume reviews advances in cancer chemotherapy research over the last 10 years. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs. Each chapter covers the drug target and biological rationale, chemotypes, clinical status and future prospects in this rapidly developing area of drug research.
Minireviews of the Neurosciences
Minireviews of the Neurosciences from Life Sciences discusses the regulation of tryptophan and tyrosine hydroxylase. This book also addresses the neurochemical correlations of synaptically active amino acids. This book deals first with the role of calcium in the central effects of biogenic amines; neuroendocrinology of human sleep; factors in central serotonergic synapse regulation; noradrenergic mediation of traumatic spinal cord; role of cyclic nucleotides in visual excitation; and function and organization of chromaffin vesicle. Other chapters consider the analysis of nerve growth factor, the sympathetic regulation of thyroid hormone secretion, and the mechanism if trans-synaptic enzyme induction. A study of the functions of the catecholamines and acetylcholine in endocrine regulation is presented. The final chapters examine the effects of brain monoamines in male sexual behavior and the behavior of L-dopa in Parkinson's disease. The book can provide useful information to neurologists, students, and researchers.
Ras Superfamily Small G Proteins: Biology and Mechanisms 1
This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.
The Analysis of Regulatory DNA: Current Developments, Knowledge and Applications Uncovering Gene Regulation
A major goal of integrative research is understanding regulatory networks to such an extent as to allow researchers to model developmental and stress responses. Regulatory networks of living systems include complex and vast interactions between proteins, metabolites, RNA, various signaling molecules and DNA. One aspect of systems biology is understanding the dynamics of protein-DNA interactions affecting gene expression that are caused by transcription factors (TFs) and chromatin remodeling factors. This e-book provides a resource for summarizing current knowledge eukaryotic transcription and explores cis-elements and methods for their analysis, prediction and discovery. The book also presen...
Cell Regulation by Intracellular Signals
In 1980, the IVth International Cyclic Nucleotide Conference was held in Brussels. As this meeting attracted many investigators involved in cyclic nucleotides and calcium role in intracellular regulation, it was thought that this opportunity could be used to organize, prior to the Congress, an in-depth introductory course on the subject. This was carried out as a NATO Advanced Study Institute. The participants included Ph. D. students and M. D. s engaged in a research training, but also fully trained and well known researchers who wanted a refresher course on the whole subject. During the course, most of the participants and lecturers asked to be provided with a text summarizing the basic le...
Peril in the Ponds
When deformed frogs-many with missing legs or eyes, footless stumps, or misshapen jaws-began to emerge from Minnesota wetlands, alarm bells went off. What caused such deformities? Pollution? Ultraviolet rays? Biological agents? And could the mysterious cause also pose a threat to humans? Former government biologist Judy Helgen provides an inside view of a highly charged environmental issue that continues to spark controversy among scientists, politicians, and government agencies. Book jacket.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
