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Organized Multienzyme Systems: Catalytic Properties
Organized Multienzyme Systems: Catalytic Properties describes the kinetic and catalytic properties of organized enzyme systems. This book is composed of nine chapters that specifically cover both immobilized and naturally occurring systems. The first two chapters examine the nature and function of enzyme organization in the mitochondrion, as well as the structural/functional coupling of the components in energy-transducing membrane systems. These topics are followed by discussions on ""dynamic compartmentation"" in soluble multienzyme systems; the allosteric enzyme systems; and allosterism in reversibly adsorptive enzyme systems. Other chapters explore model studies with specific immobilized...
Modulation by Covalent Modification
Current Topics in Cellular Regulation: Volume 27, Modulation by Covalent Modification is a compendium of papers dealing with the coordination, function, or control of cellular metabolism, particularly on modulation by covalent modification. One paper reviews the cyclic cascade model in metabolic regulation that shows the model's applicability to all covalent interconvertible enzyme systems, such as those modified by phosphorylation, ADP-ribosylation, carboxymethylation, acetylation, and sulfation. Another paper discusses the hypothesis that smooth muscle contraction is regulated by a calcium-dependent phosphorylation of the myosin molecule. Studies made by Sellers and Pato suggest that a pho...
Enzyme Catalysis and Control
Current Topics in Cellular Regulation: Volume 24, Enzyme Catalysis and Control is a compendium of papers that discusses phosphoryl transfer reactions, the role of water on the free energy of hydrolysis of pyrophosphate, and the hormonal actions of vitamin D. Other papers describe the regulation lipid metabolism by a lipid-carrying protein, the GABA, and taurine enzymes in mammalian brain. One paper examines the role of vitamin D in the metabolism of cells, as well as in the whole animal. Upon absorption in the body, the vitamin undergoes various metabolic transformations before interacting with specific receptors, and then inducting the genome in the target tissues to generate biological and...
Current Topics in Cellular Regulation
Current Topics in Cellular Regulation: Volume 23 is a collection of papers that discusses pyruvate carboxylase, the regulation of carbohydrate metabolism, and the plasma membrane ATPase of fungi or plants. Other papers deal with adrenergic control of phosphofructokinase, protein phosphatase, as well as the regulation of polypeptide precursors of mature mitochondrial proteins. One paper explains the three dimensional structure of pyruvate carboxylase and its reaction mechanism. Electron microscopic analyses show that four monomers of pyruvate carboxylases isolated from vertebrate sources form a tight tetrahedron-like structure. Another paper describes the regulation of fructose 2,6-bisphospha...
Perspectives in Biotechnology
This book is the proceedings of a NATO Advanced Studies Institute organized jointly by LNETI, the National Laboratories of the Ministry of Industry of the Portuguese Government and The Institute for Biotechnological Studies in the UK. The ASI was held in 1985 on the beautiful peninsula of Troia, once the site of a flourishing Roman salt industry. The course was the first in the NATO "Double Jump Programme" specifically aimed to promote industrial and academic participation and cooperation. As such, contributions across the whole field of biotechnology were planned and the present volume represents perspectives from specialists in different areas. Biotechnology has been defined in a recent OECD publication as "the application of scientific and engineering principles to the processing of materials by biological agents to provide goods and services" and the contents of this book, which often describe research from interdisciplinary groups, reflect this title. The value of the ASI was further enhanced by many first class poster contributions from the participants.
Cell Chemistry and Physiology: Part I
This is the first of a 4-volume module that is an introduction to the study of cell chemistry and physiology. It is not intended to be encyclopedic in nature but rather a general survey of the subject with an emphasis on those topics that are central to an understanding of cell biology and those that are certain to become of increasing importance in the teaching of modern medicine.We have followed what appeared to as to be the logical divisions of the subject beginning with proteins. Allewell and her colleagues stress the point that proteins fold spontaneously to form complex three-dimensional structures and that some of them unfold with the help of proteins called chaperones. Michaelis-Ment...
Shaping Science with Rhetoric
How do scientists persuade colleagues from diverse fields to cross the disciplinary divide, risking their careers in new interdisciplinary research programs? Why do some attempts to inspire such research win widespread acclaim and support, while others do not? In Shaping Science with Rhetoric, Leah Ceccarelli addresses such questions through close readings of three scientific monographs in their historical contexts—Theodosius Dobzhansky's Genetics and the Origin of Species (1937), which inspired the "modern synthesis" of evolutionary biology; Erwin Schrödinger's What Is Life? (1944), which catalyzed the field of molecular biology; and Edward O. Wilson's Consilience (1998), a so far not entirely successful attempt to unite the social and biological sciences. She examines the rhetorical strategies used in each book and evaluates which worked best, based on the reviews and scientific papers that followed in their wake. Ceccarelli's work will be important for anyone interested in how interdisciplinary fields are formed, from historians and rhetoricians of science to scientists themselves.
Progress in Biophysics and Molecular Biology
Progress in Biophysics and Molecular Biology, Volume 32 summarizes the significant progress that has been made in the fields of biophysics and molecular biology. Topics range from metabolic regulation and transfer RNA to cellular metabolism and prokaryotic and eukaryotic ribosomes. This volume consists of five chapters and begins with a discussion of mathematical models used in the study of metabolic regulation, with emphasis on the energy metabolism of eukaryotes. The next chapter examines the possible functions of transfer RNA minor components, paying particular attention to the principle of location-function relationships. The reader is also introduced to spatial-functional correlations in cellular metabolism and highlights the role of organize multienzyme systems, along with the fundamentals of ribosome structure and function in prokaryotes and eukaryotes. A chapter that analyzes the structures and functions of transfer RNA concludes the book. This book will be of interest to scientists, students, and researchers working in the fields of biophysics and molecular biology.
