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This book provides the latest research progress on genome editing in cardiovascular and metabolic diseases and includes bioinformatics research methodology of genome editing. Genome editing is a genetic engineering technique precisely modified specific target genes of organism genome, which has been applied to basic theoretical research and production applications from plants and animals to gene therapy of human beings. Cardiovascular and metabolic diseases have become major factors affecting human health worldwide. This book contains information about bioinformatics, genome editing in cardiovascular diseases, genome editing in metabolic diseases and therapeutic effects. It will be useful for biologist, cardiologist, cardiovascular surgeons, endocrinologist, internists, nurses, undergraduate and graduate students in medicine and cell biology and others interested in cardiovascular and metabolic medicine.
The Shroud at the Court analyses, through various essays characterized by a multidisciplinary and diachronic perspective, the strict ties created between the Shroud and the Savoy court from the fifteenth to twentieth centuries. Presented as proof of the divine legitimacy of Savoy lineage, the Shroud (of which the Savoy dynasty came into possession in 1453, keeping it first in Chambéry and then from 1578 in Turin) was central to their propagandistic strategies. The court – its spaces, protagonists, and rituals – became the natural setting for a relationship reinforced over time through customs, ceremonies, and images intended to celebrate the excellence of the Savoy, both within their own state and in Europe’s “society of princes”. Contributors are Paola Caretta, Paolo Cornaglia, Paolo Cozzo, Davide De Franco, Bernard Dompnier, Laura Gaffuri, Pierangelo Gentile, Luisella Giachino, Andrea Merlotti, Frédéric Meyer, Andrea Nicolotti, Almudena Pérez de Tudela, Laurent Ripart, Alessandro Serra and Franca Varallo.
The 1st series is a collection chiefly of medieval documents, supplemented by the Appendice in 9 vols. containing minor documents, letters, bibliographical and biographical notices. Beginning with the new series in 1855 the Archivio contains Documenti e memorie, Rassegna bibliografica, Necrologie correspondenza, annunzi bibliografici, etc.
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Due to the success of Microbiome and Machine Learning, which collected research results and perspectives of researchers working in the field of machine learning (ML) applied to the analysis of microbiome data, we are launching the second volume to collate any new findings in the field to further our understanding and encourage the participation of experts worldwide in the discussion. The success of ML algorithms in the field is substantially due to their capacity to process high-dimensional data and deal with uncertainty and noise. However, to maximize the combinatory potential of these emerging fields (microbiome and ML), researchers have to deal with some aspects that are complex and inherently related to microbiome data. Microbiome data are convoluted, noisy and highly variable, and non-standard analytical methodologies are required to unlock their clinical and scientific potential. Therefore, although a wide range of statistical modelling and ML methods are available, their application is only sometimes optimal when dealing with microbiome data.
Italian Futurist Poetry contains more than 100 poems (both Italian and English versions) by sixty-one poets from across Italy.