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This comprehensive monograph on the role of protein modulation in cancer therapeutics focuses on targeting molecules that regulate protein stability in a variety of tumors. Topics covered include ubiquitin ligases, deubiquitinating enzymes, and the proteasome.
New insights into the molecular biology of childhood leukemias have stimulated numerous advances in diagnostic methods, strategies for risk assessment and the development of novel therapy for genetic subtypes of the diseases. Fully revised and updated, this new edition of Childhood Leukemias provides the most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases. Beginning with an overview of history, cell biology, and pathology, subsequent chapters review approaches in the evaluation and management of specific leukemias, new therapeutic development and the unique pharmacodynamics and pharmacogenetics of individual patients. New chapters include epigenetics of leukemias, leukemias in patients with Down syndrome and leukemia in adolescents and young adults. The final section covers the complications associated with the disease or its treatment and supportive care during and after treatment. Authored by leading experts, this is a 'must-have' for any physician or investigator who deals with leukemias in childhood.
From a journalist and foreign correspondent, the harrowing history of how an economic crisis and far-right extremists catalyzed a shocking resurgence of violence in 21st-century Germany. Not long after the Berlin Wall fell, three teenagers became friends in the East German town of Jena. It was a time of excitement, but also of economic crisis: some four million East Germans found themselves out of jobs. The friends began attending far-right rallies with people who called themselves National Socialists: Nazis. Like the Hitler-led Nazis before them, they blamed minorities for their ills. From 2000 to 2011, they embarked on the most horrific string of white nationalist killings since the Holoca...
This book offers a concise overview of key events in North American history, focusing on the military contributions of Hispanic Americans. It pays tribute to the bravery and service of Hispanic men and women who have played and continue to play a vital role in America's defense.
This document pays tribute to the Hispanic American (HA) men and women who have served and continue to serve with courage and distinction in America's defense. Contents: overview (1492-1989); a salute to Hispanic fighter aces; (HA) recipients of the Medal of Honor; HA hostages during the takeover of the U.S. Embassy in Iran; HA officer killed in action in Libya; Navy ships christened in honor of Hispanics; HA generals and flag officers by military service; a selection of HA officer personnel; highest ranking HA enlisted personnel; the military academies and HA; HA civilians in DoD; HA within DoD. Over 100 photos.
Fruit and Vegetable Phytochemicals: Chemistry, Nutritional Value and Stability provides scientists in the areas of food technology and nutrition with accessible and up-to-date information about the chemical nature, classification and analysis of the main phytochemicals present in fruits and vegetables – polyphenols and carotenoids. Special care is taken to analyze the health benefits of these compounds, their interaction with fiber, antioxidant and other biological activities, as well as the degradation processes that occur after harvest and minimal processing.
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"Teresa Lozano Long Institute of Latin American Studies."