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Immunoglobulins
Since the discovery more than thirty years ago that antibody actlvlty could be localized to discrete plasma protein fractions, the study of immunoglobulin struc ture and function has dominated the field of immunochemistry. During this time, sources of homogeneous immunoglobulin molecules have been discovered, the subunit nature of the proteins has been defined, and the three-dimensional struc tures of the antigen-recognition portion of several antibody molecules have been elucidated. Insights into the complicated genetic control of these proteins are being gained rapidly through analysis of amino acid sequences of naturally occurring and induced homogeneous immunoglobulins. Immunoglobulins h...
Safeguarding German-American Relations in the New Century
American-German relations are in transition. A number of explanations have been given for this fact: some focusing on the personalities of politicians, some on political and attitudinal disparities, still others pointing to disagreements about foreign policy objectives since the end of the Cold War and 9/11. This volume, written by American and German scholarly experts, while not denying the relevance and validity of such explanations of the transatlantic estrangement, address the extent, resilience, and the causes of misconceptions, misunderstandings, and confrontations in the transatlantic relationship as well as highlighting commonalities and enduring ties between the U.S. and Germany. Th...
Biology of Sharks and Their Relatives
Winner of Choice Magazines Outstanding Academic Title award, January 2005! Sharks and their relatives are the subjects of tremendous interest. The publics fascination is influenced by their roles in movies and popular literature, while the media races to cover stories of predators endangering helpless humans. The alarming threat to shark popul
Immunobiology of the Shark
Immunity studies in sharks over the past three decades have produced some remarkable discoveries. If one message rings true, it is that alternative animal model systems, such as sharks and their relatives, have contributed very substantially to a better understanding of the development evolution of our own immune system. Immunobiology of the Shark describes the cellular, genetic, and molecular specifics of immune systems in sharks. Diverse approaches were employed to study the immunobiology of the shark from basic microscopic observations to detailed genome annotation. The book also raises a series of fascinating questions, which can be addressed experimentally using today’s technology. This book will be a valuable resource for mainstream immunologists, comparative immunologists, geneticists, ecologists, evolutionary biologists, and investigators engaged in shark research. The book also aims to illustrate the magnificence of these animals as model systems and underscores the importance of their study to further understand their complex, and often enigmatic, biology.
Host and Microbe Adaptations in the Evolution of Immunity
The evolution of metazoans has been accompanied by new interfaces with the microbial environment that include biological barriers and surveillance by specialized cell types. Increasingly complex organisms require increased capacities to confront pathogens, achieved by co-evolution of recognition mechanisms and regulatory pathways. Two distinct but interactive forms of immunity have evolved. Innate immunity, shared by all metazoans, is traditionally viewed as simple and non-specific. Adaptive immunity possesses the capacity to anticipate new infectious challenges and recall previous exposures; the most well-understood example of such a system, exhibited by lymphocytes of vertebrates, is based...
