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Background: Emerging infectious diseases (EID) have posed a recurring threat to human civilizations throughout history. The list of emerging infections continues to grow with a diverse set of pathogens against which we have inadequate counter measures. Human immunodeficiency virus (HIV) is perhaps the EID that defines our times, taking well over a decade before rates of new infection could be curbed following identification of the etiologic agent in 1983. Deep study of most EID reveals the intricate complexity and connectedness of humans, animals, pathogens, vectors, and environ. Ongoing outbreaks of Ebola and Lassa fever emphasize how population expansion may create niches and opportunity f...
Information on, and investigation of, the epidemiology and methods of vector-borne diseases is usually incorporated only sparsely into books about the epidemiology of infectious diseases. The most generally accessible sources are the WHO’s annual malaria guidelines and annual World Malaria Reports. In contrast, the details and findings of research are found in specialist journals, and explain the minute details of a particular situation. This book is designed for people who need to investigate the sources of disease, and report their findings. Although it references hundreds of peer-reviewed studies, it presents the procedures that can be used by vector control and epidemiologists in strai...
A complex exchange of signals between endothelial cells and tissues occurs during steady-state and in inflammatory conditions. These interactions involve numerous cell types including an active contribution from endothelial cells and occur on both sides of the endothelial monolayer. In addition to functioning as selective permeability barriers, it is increasingly recognized that local cell attraction to endothelial cells provides the potential for focal interactions between relevant cells. In this context, cellular interactions taking place at the surface of the endothelium and within the perivascular spaces are thought to initiate crucial steps in the generation and shaping of immune respon...
This book reviews the current state of health research and concludes that: more investment is needed, research need to be managed more effectively to help strengthen health systems and build public confidence in science; stronger emphasis should be placed on translating knowledge into action. There are five sections: learning to improve health, gives an overview and some historical perspective; towards a scientific basis for health systems; strengthening health research systems; linking research to action; and recommendations and an action plan.
Arthropod-borne viruses (arboviruses) are the causative agents of significant morbidity and mortality among humans and domestic animals globally. They are maintained in complex biological life cycles, involving a primary vertebrate host and a primary arthropod vector. While all known arboviruses are zoonotic pathogens, their emergence as human pathogens is associated with dramatic increases of human population growth leading to uncontrolled urbanization, changes in land and water use, changes in agricultural practices, new irrigation systems and deforestation. This book brings together a panel of expert arbovirologists to produce a timely review of the rapidly expanding arbovirus research li...
Graphene, a single sheet of graphite, has an unconventional electronic structure that can be described in terms of massless Dirac Fermions. This book presents the frontiers of graphene research ranging from important issues in condensed matter physics and chemistry to advanced device applications.