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This book introduces molecular imaging and Target Therapy in various cancers. The first part is the subjects and primary focused on the basics of nuclear physics, radiation dosimetry, nuclear medicine equipment and small animal imaging equipment. The second part is about the radiopharmaceutical and commonly used clinical radiopharmaceuticals, including positron emission imaging agent, single photon emission imaging agent, and radionuclide therapy agents as well as their radioactive preparation, quality control, and a brief clinical application were included. Also, this part introduces a number of new imaging agents which were potential value of clinical applications. In the third part, the c...
A reconsideration of the Spanish crown's involvement with technology and the sciences.
The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.
Treedom is an exploration of Japan's most well-known treehouse builder Takashi Kobayashi. Takahashi, who has been featured in the New York Times and on Animal Planet's Treehouse Masters, as well as many television programs, newspapers, and magazines in Japan, examines being an outcast in a rigid society of rules and conformity and finding salvation in the trees. Treedom, filled with photography, poetry, and Takashi's personal accounts of treehouse building, describes how treehouse living is not just a lifestyle but a philosophy.
The Spanish conquest of the Americas in the 16th century was one of the most important and cataclysmic events in history. Spanish expeditions endured incredible hardships in order to open up the lands of the 'New World', and few stories in history can match these for drama and endurance. In Conquistadors, Michael Wood follows in the footsteps of some of the greatest of the Spanish adventurers travelling from the forests of Amazonia to Lake Titicaca, the deserts of North Mexico, the snowpeaks of the Andes and the heights of Machu Picchu. He experiences the epic journeys of Cortes, Pizarro, Orellana and Cabeza de Vaca, and explores the turbulent and terrifying events surrounding the Spanish conquest of the Aztec and Inca empires. Wood brings these stories to vivid life, highlighting both the heroic accomplishments and the complex moral legacy of the European invasion. Conquistadors is Michael Wood at his best - thoughtful, provocative and gripping history.